Results 41 to 50 of about 25,483,142 (313)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Parameterized Reduced-Order Models for Probabilistic Analysis of Thermal Protection System Based on Proper Orthogonal Decomposition

Aerospace
The thermal protection system (TPS) represents one of the most critical subsystems for vehicle re-entry. However, due to uncertainties in thermal loads, material properties, and manufacturing deviations, the thermal response of the TPS exhibits ...
Kun Zhang, Jianyao Yao, Wenxiang Zhu, Zhifu Cao, Teng Li, Jianqiang Xin   +5 more
doaj   +1 more source

Manifold Hypothesis in Data Analysis: Double Geometrically-Probabilistic Approach to Manifold Dimension Estimation [PDF]

, 2021
Alexander Ivanov, Gleb V. Nosovskiy, Alexey Chekunov, D. A. Fedoseev, В. А. Кибкало, Mikhaïl Nikulin, Fedor Popelenskiy, Stepan Komkov, I. L. Mazurenko, Aleksandr Petiushko   +9 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Análise probabilística do concreto reforçado com fibras utilizado na construção do dique seco do Estaleiro Rio Grande

Revista IBRACON de Estruturas e Materiais
A variabilidade da resistência do concreto torna fundamental a utilização de metodologias estatísticas capazes de estabelecer parâmetros para a aceitação das estruturas.
F. C. Magalhães, M. V. Real
doaj   +1 more source

Incorporating the effect of ALS-derived DEM uncertainty for quantifying changes due to the landslide in 2011, Mt. Umyeon, Seoul

GIScience & Remote Sensing, 2020
The landslide, which occurred at Umyeon mountain (Mt. Umyeon) in Seoul, Korea in 2011, was a prime example that raised awareness about the landslide in the highly urbanized area.
Mi-Kyeong Kim, Hong-Gyoo Sohn, Seongsam Kim   +2 more
doaj   +1 more source

The Effect of Targeted Field Investigation on the Reliability of Axially Loaded Piles: A Random Field Approach

Geosciences, 2020
This work deals with the effect of targeted field investigation on the reliability of axially loaded piles, aiming at an optimal serviceability and ultimate limit state design.
Panagiotis Christodoulou, Lysandros Pantelidis, Elias Gravanis   +2 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source