Results 61 to 70 of about 22,531,219 (286)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
On the probabilistic min spanning tree Problem [PDF]
, 2010 International audienceWe study a probabilistic optimization model for min spanning tree, where any vertex v i of the input-graph G(V, E) has some presence probability p i in the final instance G′ ⊂ G that will effectively be optimized.
Paschos, V.T. +10 more
core +1 more source
Bearing Capacity of Strip Foundations on Shale Rock Masses with Rheological Behaviour: Probabilistic Based Approach [PDF]
مهندسی عمران شریفPredicting the bearing capacity of rock masses can be challenging when the values of rock mass properties have high uncertainty. This challenge becomes even greater when the rock mass exhibits time-dependent behavior.
Faraz Motamedi Mamaghani +2 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Computation of distances for regular and context-free probabilistic languages [PDF]
, 2008 Several mathematical distances between probabilistic languages have been investigated in the literature, motivated by applications in language modeling, computational biology, syntactic pattern matching and machine learning.
Satta, Giorgio +5 more
core +1 more source
Geosciences, 2018 A simplified geostatistical approach was adopted to assess the effect of spatial variability of soil properties on slope stability analysis in order to understand continental margin geologic processes and potential geohazards for an area of the central ...
Kevin MacKillop +4 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
A review of probabilistic analysis in orthopaedic biomechanics
Probabilistic analysis methods are being increasingly applied in the orthopaedics and biomechanics literature to account for uncertainty and variability in subject geometries, properties of various structures, kinematics and joint loading, as well as ...
Laz, P. J., Browne, M.
core +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Applied SciencesEnsuring the stability of surrounding rock in underground excavations is a critical prerequisite for safe mining operations. This study examines the mechanisms of wedge failure formation and determines the performance of a combined support system (rock ...
Vladimir Demin +6 more
doaj +1 more source