Results 71 to 80 of about 164,916 (266)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
GIScience & Remote Sensing, 2020 The landslide, which occurred at Umyeon mountain (Mt. Umyeon) in Seoul, Korea in 2011, was a prime example that raised awareness about the landslide in the highly urbanized area.
Mi-Kyeong Kim +2 more
doaj +1 more source
Geosciences, 2020 This work deals with the effect of targeted field investigation on the reliability of axially loaded piles, aiming at an optimal serviceability and ultimate limit state design.
Panagiotis Christodoulou +2 more
doaj +1 more source
Bearing capacity of eccentrically loaded strip footing on spatially variable cohesive soil
Studia Geotechnica et Mechanica, 2021 The study considers the bearing capacity of eccentrically loaded strip footing on spatially variable, purely cohesive soil. The problem is solved using the random finite element method.
Dobrzański Jędrzej, Kawa Marek
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Revista IBRACON de Estruturas e MateriaisA variabilidade da resistência do concreto torna fundamental a utilização de metodologias estatísticas capazes de estabelecer parâmetros para a aceitação das estruturas.
F. C. Magalhães, M. V. Real
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Geophysical Research LettersAnomalous precipitation, with unexpected intensity and/or spatiotemporal structures, makes flood risk management in the East Asian monsoon regions challenging, where interacting circulation systems generate highly variable precipitation events.
Wenpeng Zhao +8 more
doaj +1 more source
Applied Sciences, 2018 Global Nickel (Ni) smelters’ have been experiencing profit losses for nearly a decade due to the 2008 recession still impacting the industry, oversupply, and fluctuating ore quality.
Ho-Hyun Jeong +2 more
doaj +1 more source