Results 71 to 80 of about 890,561 (342)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Applied SciencesGeosynthetic-reinforced embankments are subject to two primary failure mechanisms: bond failure and rupture. Bond failure occurs when the critical slip surface extends beyond the reinforced zone, while rupture occurs when the slip surface intersects the ...
Shen Zhang +6 more
doaj +1 more source
Probabilistic Analysis for Randomized Game Tree Evaluation
, 2004 We give a probabilistic analysis for the randomized game tree evaluation algorithm of Snir. We first show that there exists an input such that the running time, measured as the number of external nodes read by the algorithm, on that input is maximal in ...
Khan, Tämur Ali, Neininger, Ralph
core +2 more sources
Supervised probabilistic principal component analysis [PDF]
Proceedings of the 12th ACM SIGKDD international conference on Knowledge discovery and data mining, 2006 Principal component analysis (PCA) has been extensively applied in data mining, pattern recognition and information retrieval for unsupervised dimensionality reduction. When labels of data are available, e.g., in a classification or regression task, PCA is however not able to use this information.
Yu, S. +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Applied Sciences, 2018 Global Nickel (Ni) smelters’ have been experiencing profit losses for nearly a decade due to the 2008 recession still impacting the industry, oversupply, and fluctuating ore quality.
Ho-Hyun Jeong +2 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
A new approach to structural seismic responses in Mataram City: Based on the Probabilistic Seismic Hazard Analysis (PSHA) results obtained after Lombok earthquakes 2018 [PDF]
, 2022 Ni Nyoman Kencanawati +3 more
openalex +1 more source
Insights into a long life without cancer: The case of the bowhead whale
Molecular Oncology, EarlyView.Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley +1 more source