Results 51 to 60 of about 25,483,142 (313)
Bearing capacity of eccentrically loaded strip footing on spatially variable cohesive soil
Studia Geotechnica et Mechanica, 2021 The study considers the bearing capacity of eccentrically loaded strip footing on spatially variable, purely cohesive soil. The problem is solved using the random finite element method.
Dobrzański Jędrzej, Kawa Marek
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Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Applied SciencesGeosynthetic-reinforced embankments are subject to two primary failure mechanisms: bond failure and rupture. Bond failure occurs when the critical slip surface extends beyond the reinforced zone, while rupture occurs when the slip surface intersects the ...
Shen Zhang +6 more
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Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Applied Sciences, 2018 Global Nickel (Ni) smelters’ have been experiencing profit losses for nearly a decade due to the 2008 recession still impacting the industry, oversupply, and fluctuating ore quality.
Ho-Hyun Jeong +2 more
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A new approach to structural seismic responses in Mataram City: Based on the Probabilistic Seismic Hazard Analysis (PSHA) results obtained after Lombok earthquakes 2018 [PDF]
, 2022 Ni Nyoman Kencanawati +3 more
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Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Evaluation of the stability of a highway slope through numerical modeling
Dyna, 2017 Mass movement in natural slopes can cause great material and human loss for society. In this context, stability analyses become quite complex since there are a large number of uncertainties involved in the interpretation of the problem.
Gabriel Steluti Marques +1 more
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