Results 71 to 80 of about 33,963 (308)

Why There Cannot be a Single Probabilistic Measure of Coherence [PDF]

, 2005
Bayesian Coherence Theory of Justification or, for short, Bayesian Coherentism, is characterized by two theses, viz. (i) that our degree of confidence in the content of a set of propositions is positively affected by the coherence of the set, and (ii ...
Bovens, Luc, Bovens, L, Hartmann, Stephan   +2 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

ITERATIVE PROBABILISTIC SOLUTION METHOD OF INTERSECTORAL BALANCE LINEAR EQUATION

Advanced Engineering Research, 2011
The new solution method for the systems of linear algebraic equations based on the application of the measure theory in the probabilistic space is stated. The possibility of its application for the solution of the equation of linear intersectoral balance
Veronika S. Strelchenko, Igor V. Boguslavskiy   +1 more
doaj  

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

ITERATIVE PROBABILISTIC SOLUTION METHOD OF INTERSECTORAL BALANCE LINEAR EQUATION

Вестник Донского государственного технического университета, 2018
The new solution method for the systems of linear algebraic equations based on the application of the measure theory in the probabilistic space is stated. The possibility of its application for the solution of the equation of linear intersectoral balance
Veronika S. Strelchenko, Igor V. Boguslavskiy   +1 more
doaj  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Multi-criteria group decision-making with extended ELECTRE III method and regret theory based on probabilistic interval-valued intuitionistic hesitant fuzzy information

Complex & Intelligent Systems
The modern decision-making environment is complex and dynamic. Global supply chain networks are increasingly exposed to unsystematic risks. Therefore, decision-makers need greater flexibility and precision to better manage uncertain market changes and ...
Chuanyang Ruan, Shicheng Gong, Xiangjing Chen   +2 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Maximal traces and path-based coalgebraic temporal logics

, 2011
This paper gives a general coalgebraic account of temporal logics whose semantics involves a notion of computation path. Examples of such logics include the logic CTL* for transition systems and the logic PCTL for probabilistic transition systems.
Cirstea, Corina, Corina Cîrstea
core   +1 more source