Results 111 to 120 of about 14,817,250 (289)

Risk-Optimal Arrangement of Stiffeners in Steel Plate Shear Walls With Door Opening

Frontiers in Built Environment, 2018
Placement of steel plate shear walls (SPSW) in the building cores around the elevators and stairs necessitates door-type openings in these systems. Because of large dimensions of door openings, the energy dissipation capacity drops significantly and thus,
Parisa Rostami, Mojtaba Mahsuli
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Long-term desalinated water demand and investment requirements: a case study of Riyadh

Journal of Water Reuse and Desalination, 2018
The Kingdom of Saudi Arabia (KSA) is situated in an arid region and faces a chronic challenge to meet its increasing water demand. Riyadh is the capital of KSA and home to about six million people. The water demand is mostly met by groundwater resources (
O. K. M. Ouda, Y. Khalid, A. H. Ajbar, M. Rehan, K. Shahzad, I. Wazeer, A. S. Nizami   +6 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Search and Retrieval]: Retrieval models

, 2008
There have been a number of prior attempts to theoretically justify the effectiveness of the inverse document frequency (IDF). Those that take as their starting point Robertson and Spärck Jones’s probabilistic model are based on strong or complex ...
Robertson-spärck Jones, Probabilistic Model   +1 more
core  

A Probabilistic Model For Chord Progressions.

, 2005
[TODO] Add abstract here.
Paiement, Jean-François, Eck, Douglas, Bengio, Samy   +2 more
openaire   +5 more sources

A Note for Probabilistic Model of Polymer Crystallization in Temperature Gradients

Crystals, 2019
A polymer crystallization kinetics model is the most important way to characterize the crystallization rate of polymers. Because polymers are poor heat conductors, the cooling of thick-walled shapes results in temperature gradients.
Chunlei Ruan, Yunlong Lv
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Natural Gradient Boosting for Probabilistic Prediction of Soaked CBR Values Using an Explainable Artificial Intelligence Approach

Buildings
The California bearing ratio (CBR) value of subgrade is the most used parameter for dimensioning flexible and rigid pavements. The test for determining the CBR value is typically conducted under soaked conditions and is costly, labour-intensive, and time-
Esteban Díaz, Giovanni Spagnoli
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source