Results 41 to 50 of about 360,925 (264)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Probabilistic Solar Generation Forecasting for Rapidly Changing Weather Conditions

IEEE Access
Probabilistic solar generation forecasting provides a better means of quantifying generation uncertainties for power grid operations by providing a range of potential power outputs rather than a single-point estimate. The traditional probabilistic models
Cheng Lyu, Sara Eftekharnejad
doaj   +1 more source

Using a Recurrent Neural Network to Reconstruct Quantum Dynamics of a Superconducting Qubit from Physical Observations

Physical Review X, 2020
At its core, quantum mechanics is a theory developed to describe fundamental observations in the spectroscopy of solids and gases. Despite these practical roots, however, quantum theory is infamous for being highly counterintuitive, largely due to its ...
E. Flurin, L. S. Martin, S. Hacohen-Gourgy, I. Siddiqi   +3 more
doaj   +1 more source

Use and Communication of Probabilistic Forecasts [PDF]

, 2014
Probabilistic forecasts are becoming more and more available. How should they be used and communicated? What are the obstacles to their use in practice? I review experience with five problems where probabilistic forecasting played an important role. This
Raftery, Adrian E.
core  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Exploring new probability density functions related to Brownian local time

Kuwait Journal of Science
This work introduces a new family of probability density functions constructed from 𝐄[𝐿𝐵(1, 𝑥)], the expectation of the Brownian local time 𝐿𝐵(1, 𝑥) at time one.
Omar Allaoui, Aissa Sghir, Mohamed Mellouk, Mhamed Eddahbi   +3 more
doaj   +1 more source

Limit theorems for nondegenerate U-statistics of continuous semimartingales

, 2014
This paper presents the asymptotic theory for nondegenerate $U$-statistics of high frequency observations of continuous It\^{o} semimartingales. We prove uniform convergence in probability and show a functional stable central limit theorem for the ...
Podolskij, Mark, Schmidt, Christian, Ziegel, Johanna F.   +2 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Integration of geophysical datasets by a conjoint probability tomography approach: application to Italian active volcanic areas

Annals of Geophysics, 2008
We expand the theory of probability tomography to the integration of different geophysical datasets. The aim of the new method is to improve the information quality using a conjoint occurrence probability function addressed to highlight the existence of ...
D. Patella, P. Mauriello
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source