Results 61 to 70 of about 13,686,872 (271)

Application of reliability theory and risk management in sustainable agricultural construction infrastructure in high-risk regions

Budownictwo o Zoptymalizowanym Potencjale Energetycznym
Reliability theory, probabilistic modeling, and risk management are tools that allow for deter-mining the probability of correct operation under specific times and conditions, better under-standing complex real-world systems by accounting for their ...
Martin Vartanov, Nana Beraia, Konstantine Bziava, Marina Shogiradze   +3 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Exploring new probability density functions related to Brownian local time

Kuwait Journal of Science
This work introduces a new family of probability density functions constructed from 𝐄[𝐿𝐵(1, 𝑥)], the expectation of the Brownian local time 𝐿𝐵(1, 𝑥) at time one.
Omar Allaoui, Aissa Sghir, Mohamed Mellouk, Mhamed Eddahbi   +3 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Using a Recurrent Neural Network to Reconstruct Quantum Dynamics of a Superconducting Qubit from Physical Observations

Physical Review X, 2020
At its core, quantum mechanics is a theory developed to describe fundamental observations in the spectroscopy of solids and gases. Despite these practical roots, however, quantum theory is infamous for being highly counterintuitive, largely due to its ...
E. Flurin, L. S. Martin, S. Hacohen-Gourgy, I. Siddiqi   +3 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Weighted scoringRules: Emphasizing Particular Outcomes When Evaluating Probabilistic Forecasts

Journal of Statistical Software
When predicting future events, it is common to issue forecasts that are probabilistic, in the form of probability distributions over the range of possible outcomes. Such forecasts can be evaluated using proper scoring rules.
Sam Allen
doaj   +1 more source

On the existence of positive solutions of nonlinear elliptic equations—a probabilistic potential theory approach

Duke Mathematical Journal, 1993
We study the existence of solutions to the problem \[ \begin{cases} \Delta u+K(x) f(u)=0 \quad & \text{ in } D \\ u>0 & \text{ in } D \\ u=0 & \text{ on } \partial D. \end{cases} \tag{I} \] Our goal is to prove an existence theorem for problem (I) in a general setting by using Brownian path integration method and the potential theory.
openaire   +3 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

A Probabilistic Framework for Early-Stage Scalability Analysis in the Software Development Life Cycle

IEEE Access
Scalability is a critical non-functional requirement (NFR) for modern software systems operating under dynamic workloads and distributed environments.
Anirban Bhar, Soumyabrata Saha, Suparna Dasgupta, Sudarshan Nath, Pushpita Roy, Bikash Debnath, Soumya Bhattacharyya, Sandipan Biswas, Amrut Ranjan Jena, Kailash Pati Mandal, Shubhendu Banerjee   +10 more
doaj   +1 more source