Results 61 to 70 of about 40,428 (287)

An analysis of the exponential decay principle in probabilistic trust models [PDF]

open access: yes, 2009
Research in models for experience-based trust management has either ignored the problem of modelling and reasoning about dynamically changing principal behaviour, or provided ad hoc solutions to it. Probability theory provides a foundation for addressing
Krukow, Karl Tikjøb   +5 more
core   +1 more source

Weighted scoringRules: Emphasizing Particular Outcomes When Evaluating Probabilistic Forecasts

open access: yesJournal of Statistical Software
When predicting future events, it is common to issue forecasts that are probabilistic, in the form of probability distributions over the range of possible outcomes. Such forecasts can be evaluated using proper scoring rules.
Sam Allen
doaj   +1 more source

On the existence of positive solutions of nonlinear elliptic equations—a probabilistic potential theory approach

open access: yesDuke Mathematical Journal, 1993
We study the existence of solutions to the problem \[ \begin{cases} \Delta u+K(x) f(u)=0 \quad & \text{ in } D \\ u>0 & \text{ in } D \\ u=0 & \text{ on } \partial D. \end{cases} \tag{I} \] Our goal is to prove an existence theorem for problem (I) in a general setting by using Brownian path integration method and the potential theory.
openaire   +3 more sources

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

On-Orbit Manoeuvring Using Superquadric Potential Fields [PDF]

open access: yes, 2007
On-orbit manoeuvring represents an essential process in many space missions such as orbital assembly, servicing and reconfiguration. A new methodology, based on the potential field method along with superquadric repulsive potentials, is discussed in this
Badawy, Ahmed
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Opinion dynamics with confirmation bias. [PDF]

open access: yesPLoS ONE, 2014
Confirmation bias is the tendency to acquire or evaluate new information in a way that is consistent with one's preexisting beliefs. It is omnipresent in psychology, economics, and even scientific practices.
Armen E Allahverdyan, Aram Galstyan
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

“Can I Use My Leg Too?” Dancing with Uncertainty: Exploring Probabilistic Thinking Through Embodied Learning in a Jerusalem Art High School Classroom

open access: yesEducation Sciences
Despite increased interest in embodied learning, the role of sensorimotor activity in shaping students’ probabilistic reasoning remains underexplored. This design-based study examines how high school students develop key probabilistic concepts, including
Dafna Efron, Alik Palatnik
doaj   +1 more source

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