Results 41 to 50 of about 15,697,207 (237)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Experiments with Generalized Binary Probabilistic Independence Model [PDF]
, 1989 This paper reports experiments with the generalized binary probabilistic independence model in which more complete statistical information is used. Two basic sets of experiments, referred to as nonpredictive and predictive, have been performed on two ...
Yao, Y. Y., Wong, S. K. M.
core +5 more sources
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Log-Viterbi algorithm applied on second-order hidden Markov model for human activity recognition
International Journal of Distributed Sensor Networks, 2018 Recognition of human activities is getting into the limelight among researchers in the field of pervasive computing, ambient intelligence, robotic, and monitoring such as assistive living, elderly care, and health care.
Yang Sung-Hyun +3 more
doaj +1 more source
Comparative analysis of behavioral models for adaptive learning in changing environments
Frontiers in Computational Neuroscience, 2016 Probabilistic models of decision making under various forms of uncertainty have been applied in recent years to numerous behavioral and model-based fMRI studies.
Dimitrije eMarković, Stefan eKiebel
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Semantic Topic Modeling of Aviation Safety Reports: A Comparative Analysis Using BERTopic and PLSA
AerospaceAviation safety analysis increasingly relies on extracting actionable insights from narrative incident reports to support risk identification and improve operational safety.
Aziida Nanyonga +3 more
doaj +1 more source
Evaluation of Term Ranking Algorithms for Pseudo-Relevance Feedback in MEDLINE Retrieval [PDF]
Healthcare Informatics Research, 2011 ObjectivesThe purpose of this study was to investigate the effects of query expansion algorithms for MEDLINE retrieval within a pseudo-relevance feedback framework.MethodsA number of query expansion algorithms were tested using various term ranking ...
Sooyoung Yoo, Jinwook Choi
doaj +1 more source