Results 51 to 60 of about 409,370 (266)

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Malfunctions in radioactivity sensors' networks

open access: yesEPJ Web of Conferences, 2018
The capacity to promptly and efficiently detect any source of contamination of the environment (a radioactive cloud) at a local and a country scale is mandatory to a safe and secure exploitation of civil nuclear energy. It must rely upon a robust network
Khalipova Veronika   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Viabilité, probabilités, induction

open access: yesTracés, 2013
While probability calculus helps favour the credence in a future occurrence, operational research prescribes a list of controls aimed at a given objective, generally in optimizing a given criterion.
Noël Bonneuil
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Juggling Probabilities

open access: yesThe American Mathematical Monthly, 2005
The act of a person juggling can be viewed as a Markov process if we assume that the juggler throws to random heights. I make this association for the simplest reasonable model of random juggling and compute the steady state probabilities in terms of the Stirling numbers of the second kind. I also explore several alternate models of juggling.
openaire   +3 more sources

Prise de décision probabiliste spontanée chez les apprenants marocains

open access: yesAnnales de Didactique et de Sciences Cognitives
In our modern society, individuals are often faced with situations in which they have to make decisions spontaneously in an environment involving chance, in which the use of probability remains an adequate tool occupying an important status.
Zahid El M’Hamedi
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Chances and risks in medical risk communication

open access: yesGMS German Medical Science, 2015
Communication between physicians and patients in everyday life is marked by a number of disruptive factors. Apart from specific interests, mistakes, and misunderstandings on both sides, there are main factors that contribute to the risk in risk ...
Hoffrage, Ulrich, Koller, Michael
doaj   +1 more source

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