Results 61 to 70 of about 409,370 (266)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Probability Logic and Logical Probability
, 2007 Authors like Keynes, H. Jeffreys and Carnap advocated using a concept of "logical probability". Logical probability had the following properties: (a) it was representable as a function from potential states of full belief (or "evidence") to states of subjective or credal probability judgment.
openaire +4 more sources
Sensitivity of Bayesian Networks to Noise in Their Parameters
EntropyThere is a widely spread belief in the Bayesian network (BN) community that the overall accuracy of results of BN inference is not too sensitive to the precision of their parameters.
Agnieszka Onisko, Marek J. Druzdzel
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Market-Implied Risk-Neutral Probabilities, Actual Probabilities, Credit Risk and News
IIMB Management Review, 2011 Motivated by the credit crisis, this paper investigates links between risk-neutral probabilities of default implied by markets (e.g. from yield spreads) and their actual counterparts (e.g. from ratings).
Shashidhar Murthy
doaj +3 more sources
Seismic zonation of the Dead Sea Transform Fault area
Annals of Geophysics, 2000 The Dead Sea Transform Fault constitutes the northwestern boundary of the Arabian plate, accommodating the plates lateral movement relative to the African plate.
E. E. Papadimitriou +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source