Results 51 to 60 of about 1,021,568 (282)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A New Discrete Analogue of the Continuous Muth Distribution for Over-Dispersed Data: Properties, Estimation Techniques, and Application

Entropy
We present a new one-parameter discrete Muth (DsMuth) distribution, a flexible probability mass function designed for modeling count data, particularly over-dispersed data. The proposed distribution is derived through the survival discretization approach.
Howaida Elsayed, Mohamed Hussein
doaj   +1 more source

Mathematical analysis of a Markovian multi-server feedback queue with a variant of multiple vacations, balking and reneging

Discrete and Continuous Models and Applied Computational Science, 2022
In this paper, we analyze a multi-server queue with customers impatience and Bernoulli feedback under a variant of multiple vacations. On arrival, a customer decides whether to join or balk the system, based on the observation of the system size as well ...
Amina Angelika Bouchentouf, Latifa Medjahri, Mohamed Boualem, Amit Kumar   +3 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Trends in the Use of Proper Methods for Estimating Mutation Rates in Fluctuation Experiments

Axioms, 2023
The accurate quantification of mutation rates holds significance across diverse fields, including evolution, cancer research, and antimicrobial resistance. Eighty years ago, Luria and Delbrück demonstrated that the proper quantification of mutation rates
Guillem A. Devin, Alejandro Couce
doaj   +1 more source

Generalized Moment Generating Functions of Random Variables and Their Probability Density Functions [PDF]

American Journal of Applied Mathematics and Statistics, 2017
This paper seeks to develop a generalized method of generating the moments of random variables and their probability distributions. The Generalized Moment Generating Function is developed from the existing theory of moment generating function as the expected value of powers of the exponential constant.
Matthew Chukwuma Michael, Oyeka Cyprain Anene, Ashinze Mpuruoma Akudo, Igabari John Nwabueze   +3 more
openaire   +1 more source

The relation between tree size complexity and probability for Boolean functions generated by uniform random trees

, 2015
We consider a probability distribution on the set of Boolean functions in n variables which is induced by random Boolean expressions. Such an expression is a random rooted plane tree where the internal vertices are labelled with connectives And and OR ...
Genitrini, Antoine, Gittenberger, Bernhard, Kraus, Veronika, Mailler, Cécile   +3 more
core   +3 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Performance analysis of complex field network coding based on moment generating function

Tongxin xuebao, 2012
The moment generating function was introduced to analysis closed-form expression for the outage probability that the relays employ complex field network coding,and the effect on symbol error probability with various modulation mode was evaluated.Computer
Gang-zi CHEN, Jing YANG
doaj   +2 more sources

Mathematical Properties of the Binomial-Poisson Distribution

Journal of Applied Sciences and Environmental Management
This study conducts a thorough analytical exploration of the Binomial-Poisson distribution, a compound probability model where the number of Binomial trials follows a Poisson distribution. Through application of the compound distribution methodology and
A. A. Ayenigba, D. A. Afariogun, O. M. Ajao, I. K. Adebayo   +3 more
doaj   +4 more sources