Results 51 to 60 of about 7,036,065 (293)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

A Probability Generating Function Based Goodness-of-Fit Test for the Poisson–Three-Parameter Lindley Distribution

Mathematics
The Poisson–Three-Parameter Lindley (PTPL) distribution constitutes a flexible Poisson mixture model for overdispersed count data, encompassing several classical count distributions as special or limiting cases.
Francisco Novoa-Muñoz
doaj   +1 more source

Additive Trinomial Fréchet distribution with practical application

Results in Physics, 2022
This article presents an innovative model called Additive Trinomial Fré chet (ATF) distribution using six parameters. The indicated model is worthy of modeling survival data with a non-monotonic hazard rate.
Showkat Ahmad Lone, Tabassum Naz Sindhu, Fahd Jarad   +2 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

A New Discrete Analogue of the Continuous Muth Distribution for Over-Dispersed Data: Properties, Estimation Techniques, and Application

Entropy
We present a new one-parameter discrete Muth (DsMuth) distribution, a flexible probability mass function designed for modeling count data, particularly over-dispersed data. The proposed distribution is derived through the survival discretization approach.
Howaida Elsayed, Mohamed Hussein
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Mathematical Properties of the Binomial-Poisson Distribution

Journal of Applied Sciences and Environmental Management
This study conducts a thorough analytical exploration of the Binomial-Poisson distribution, a compound probability model where the number of Binomial trials follows a Poisson distribution. Through application of the compound distribution methodology and
A. A. Ayenigba, D. A. Afariogun, O. M. Ajao, I. K. Adebayo   +3 more
doaj   +4 more sources

Generating Random Samples Using Response Surface Methodology without need to Distribution of Parameters [PDF]

مجله مدل سازی در مهندسی, 2018
Many of engineering problems have nonlinear or highly nonlinear limit state functions. Different approaches have been developed in calculating of failure probability in these problems.
Mehdi Nikooei Mahani, Amir Mahmoodzadeh, Manoochehr Emamgholi   +2 more
doaj   +1 more source

Some applications of probability generating function based methods to statistical estimation [PDF]

, 2009
After recalling previous work on probability generating functions for real valued random variables we extend to these random variables uniform laws of large numbers and functional limit theorem for the empirical probability generating function.
Esquível, Manuel
core   +1 more source