Results 61 to 70 of about 706,922 (243)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
On the Wasserstein Median of Probability Measures
Journal of Computational and Graphical StatisticsThe primary choice to summarize a finite collection of random objects is by using measures of central tendency, such as mean and median. In the field of optimal transport, the Wasserstein barycenter corresponds to the Fréchet or geometric mean of a set of probability measures, which is defined as a minimizer of the sum of squared distances to each ...
Kisung You +2 more
openaire +5 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
On the Čech-Completeness of the Space of τ-Smooth Idempotent Probability Measures
AxiomsFor the set I(X) of probability measures on a compact Hausdorff space X, we propose a new way to introduce the topology by using the open subsets of the space X.
Ljubiša D. R. Kočinac +2 more
doaj +1 more source
Bernoulli trials and permutation statistics
International Journal of Mathematics and Mathematical Sciences, 1992 Several coin-tossing games are surveyed which, in a natural way, give rise to statistically induced probability measures on the set of permutations of {1,2,…,n} and on sets of multipermutations.
Don Rawlings
doaj +1 more source
A discrete limit theorem for the periodic Hurwitz zeta-function. II
Lietuvos Matematikos Rinkinys, 2016 In the paper, we prove a limit theorem of discrete type on the weak convergence of probability measures on the complex plane for the periodic Hurwitz zeta-function.
Audronė Rimkevičienė
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
On Joint Distribution of General Dirichlet Series
Nonlinear Analysis, 2003 In the paper a joint limit theorem in the sense of the weak convergence in the space of meromorphic functions for general Dirichlet series is proved under weaker conditions as in [1].
J. Genys, A. Laurinčikas
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source