Results 61 to 70 of about 434,779 (289)

The Bayesian Origin of the Probability Weighting Function in Human Representation of Probabilities

CoRR
Humans systematically misrepresent probability in a stereotyped inverse-S pattern. It has been documented for decades, but its origin remains unexplained. We propose a Bayesian encoding-decoding account in which probabilities are represented by noisy internal signals and decoded by Bayes-risk minimization.
Xin Tong, Thi Thu Uyen Hoang, Xue-Xin Wei, Michael Hahn 0001   +3 more
openaire   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Impact of renin angiotensin system inhibitor on 3-year clinical outcomes in acute myocardial infarction patients with preserved left ventricular systolic function: a prospective cohort study from Korea Acute Myocardial Infarction Registry (KAMIR)

BMC Cardiovascular Disorders, 2021
Background Patients with acute myocardial infarction (AMI) are usually treated with angiotensin-converting enzyme inhibitors (ACEIs), or angiotensin receptor blockers (ARBs) if ACEIs are not tolerated.
Kyung-Hee Kim, Byoung Geol Choi, Seung-Woon Rha, Cheol Ung Choi, Myung-Ho Jeong, Other KAMIR-NIH investigators   +5 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Development of a new microdosimetric biological weighting function for the RBE10 assessment in case of the V79 cell line exposed to ions from 1H to 238U

Physics in Medicine and Biology, 2020
An improved biological weighting function (IBWF) is proposed to phenomenologically relate microdosimetric lineal energy probability density distributions with the relative biological effectiveness (RBE) for the in vitro clonogenic cell survival ...
A. Parisi, Tatsuhiko Sato, Yusuke Matsuya, Y. Kase, G. Magrin, C. Verona, L. Tran, A. Rosenfeld, A. Bianchi, P. Olko, L. Struelens, F. Vanhavere   +11 more
semanticscholar   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

Maintaining long-term frequent tea consumption could reduce the risk of cognitive decline: results from a 10-year longitudinal study

Frontiers in Nutrition
BackgroundPrevious studies have suggested that tea may have neuroprotective effect. This study aimed to investigate the association between tea consumption frequency and cognitive decline, taking into account changes in consumption habits and selection ...
Jie Huang, Jie Huang, Hongfen Wang, Yuying Wang, Yuying Wang, Jiaqi Xu, Jiaqi Xu, Jiameng Ni, Jiameng Ni, Mengjie Li, Mengjie Li, Bin Chen, Zaixiang Tang, Zaixiang Tang, Yu Zhang, Liping Tan   +15 more
doaj   +1 more source

A Multi-Objectives Weighting Genetic Algorithm for Scheduling Resource-Constraint Project Problem in the Presence of Resource Uncertainty [PDF]

International Journal of Supply and Operations Management, 2019
Scarce resources may cause delay in completion of a project on time. In this research, a multi-objective decision making model is developed for scheduling multi-mode resource constraint scheduling problem in the presence of uncertain resources.
Aidin Delgoshaei, Aisa Aram, Vahid Mantegh, Sepehr Hanjani, Amir Hossein Nasiri, Fatemeh Shirmohamadi   +5 more
doaj   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Doubly robust estimators for generalizing treatment effects on survival outcomes from randomized controlled trials to a target population

Journal of Causal Inference, 2022
In the presence of heterogeneity between the randomized controlled trial (RCT) participants and the target population, evaluating the treatment effect solely based on the RCT often leads to biased quantification of the real-world treatment effect.
Lee Dasom, Yang Shu, Wang Xiaofei
doaj   +1 more source