Results 71 to 80 of about 246,472 (288)

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Prompting Candidates in Oral Assessment Contexts: A Taxonomy and Guiding Principles

Journal of Medical Education and Curricular Development, 2020
Prompting is an aspect of oral assessment that deserves more attention. There appears to be considerable variation in how practitioners conceptualise prompting and how it is deployed in practice.
Jacob Pearce, Neville Chiavaroli
doaj   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Kemampuan Koneksi Matematis Siswa dengan Probing Prompting Berdasarkan Nilai-nilai Islam Pada Materi Pola Bilangan [PDF]

, 2020
This study aims to determine an increase in the mathematical connection ability of students of class VIII MTs Mathlabul Falah Labuan by using the Probing-prompting learning model based on Islamic values.
Nenden Suciyati Sartika, Asep Sujana, Ridwan, Meika, Ika, Ika Meika, null Asep Sujana, null Nenden Suciyati Sartika, null Ridwan   +7 more
core   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

Red-teaming Activation Probes using Prompted LLMs

CoRR
Activation probes are attractive monitors for AI systems due to low cost and latency, but their real-world robustness remains underexplored. We ask: What failure modes arise under realistic, black-box adversarial pressure, and how can we surface them with minimal effort?
Phil Blandfort, Robert Graham
openaire   +3 more sources

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Praktikalitas Dan Keefektifan Modul Kalkulus 2 Berbasis Probing Prompting

Edumatica: Jurnal Pendidikan Matematika, 2018
Abstrak Tujuan penelitian ini adalah untuk mengembangkan modul kalkulus 2 berbasis probing prompting yang praktis dan efektif. Metode penelitian ini menggunakan model pengembangan procedural Instruksional Development Institute (IDI) yang terdiri dari 3 ...
Asmaul Husna, Nailul Himmi Hasibuan
doaj   +1 more source

Therapist behaviours in a web-based mindfulness-based cognitive therapy (eMBCT) for chronic cancer-related fatigue – Analyses of e-mail correspondence

Internet Interventions, 2020
Web-based mindfulness-based cognitive therapy (eMBCT) has been found effective in decreasing fatigue severity in patients suffering from Chronic Cancer-Related Fatigue (CCRF).
Anne Maas, Melanie P.J. Schellekens, Rosalie A.M. van Woezik, Marije L. van der Lee   +3 more
doaj   +1 more source

PENGGUNAAN TEKNIK PROBING-PROMPTING PADA PEMBELAJARAN MATEMATIKA UNTUK MENINGKATKAN KEMAMPUAN PEMECAHAN MASALAH MATEMATIS SISWA SMP [PDF]

, 2010
Penelitian ini dilakukan di SMP Negeri 12 Bandung. Metode penelitian yang digunakan berupa penelitian eksperimen. Penelitian ini dilakukan untuk mengetahui peningkatan kemampuan pemecahan masalah matematis siswa yang pembelajarannya menggunakan teknik ...
Nita Rosdiana, -
core