Results 61 to 70 of about 229,699 (289)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Penerapan Teknik Probing-Prompting untuk Meningkatkan Pemahaman Konsep Matematika Siswa [PDF]

, 2018
Kemampuan pemahaman dalam pembelajaran matematika merupakan suatu hal yang penting, karna melalui pemahaman konsep siswa dapat mengorganisasi dan mengaplikasikan pemahaman konsep yang telah diperolehnya. Selanjutnya kemampuan tersebut akan membawa siswa
Moni Upita, 261324566
core  

Probing Prompting Improves Junior High School Students' Mathematical Reasoning During the Implementation of Community Activities Restrictions [PDF]

, 2023
: This research aims to determine the effect of using the probing-prompting technique in significantly improving students' mathematical reasoning abilities in class and to determine students' responses to the application of the probing-prompting ...
Harisuddin, Muhammad Iqbal
core  

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Effectiveness of Probing-prompting Learning Models with Scaffolding Strategy to Mathematic Creative Thinking Ability and Enthusiasm

Unnes Journal of Mathematics Education, 2017
The purpose of this research was to know that the learning model ProbingPrompting with Scaffolding strategy effective on the mathematic creative thinking ability and enthusiasm.
Miftah Hafidz Alfian, Dwijanto Dwijanto, Sunarmi Sunarmi   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Red-teaming Activation Probes using Prompted LLMs

CoRR
Activation probes are attractive monitors for AI systems due to low cost and latency, but their real-world robustness remains underexplored. We ask: What failure modes arise under realistic, black-box adversarial pressure, and how can we surface them with minimal effort?
Phil Blandfort, Robert Graham
openaire   +3 more sources

Model Pembelajaran Probing Prompting dalam Meningkatkan Motivasi Belajar Sejarah

, 2020
Dalam suatu pembelajaran di ruang kelas perlu adanya inovasi, tak terkecuali dengan pembelajaran Sejarah. Aktivitas siswa dalam pembelajaran sangat bergantung pada aktivitas seorang guru. Oleh karena itu, diperlukan guru yang kreatif dan imajinatif untuk
Kristin Imanuel
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source