Results 31 to 40 of about 44,895 (266)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Indonesian Contemporary Nursing Journal, 2018 Background: High demands in all conditions require proffesional health workers. In dealing with patients, health workers need high emotional intelligence and problem solving skills that are qualified to deal with various problems.
Hasnah Hasnah +2 more
doaj +1 more source
THE PROFILE OF STUDENTS’ PROBLEM-SOLVING SKILLS TOWARD ENVIRONMENTAL POLLUTION TOPIC
Assimilation, 2023 Problem-solving is an essential skill that must be possessed by students, especially in learning biology. The purpose of this research is to determine the profile of students’ problem-solving skills in Senior High School 10 Palembang on environmental ...
Kurnia Utami +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
THE ABILITY TO SOLVE PROBLEMS WITH INFORMATIC RESOURCES IN THE FORMATION OF THE PRIMARY TEACHER [PDF]
Varela, 2018 The treatment of problem solving through computer resources has a transcendental importance for the life of young people in society. Cuban education promotes the resolution of computer problems from an early age, through the school curriculum.
Keila Irene Díaz Tejera +1 more
doaj
Students Ability to Solve Mathematical Problem Through Online Learning During Covid-19 Pandemic
Al Khawarizmi, 2022 The purpose of this study is to examine the solving skill of students on mathematical problem through online learning during COVID-19 pandemic, particularly in solving the problem related area and perimeter of trapezium.
Budi Azhari +3 more
doaj +1 more source