Results 31 to 40 of about 488,922 (314)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Prediction and Classification of Phenol Contents in Cnidium officinale Makino Using a Stacking Ensemble Model in Climate Change Scenarios

Agronomy
Recent studies have focused on using big-data-based machine learning to address the effects of climate change scenarios on the production and quality of medicinal plants.
Hyunjo Lee, Hyun Jung Koo, Kyeong Cheol Lee, Yoojin Song, Won-Kyun Joo, Cheol-Joo Chae   +5 more
doaj   +1 more source

PENGARUH MODEL PEMBELAJARAN CREATIVE PROBLEM SOLVING BERBANTUAN MEDIA MAPLE 11 TERHADAP KEMAMPUAN PEMECAHAN MASALAH MATEMATIS

Al-Jabar, 2015
Lack of mathematical problem solving ability of students in Bandar Lampung MAN 2 due learners trouble completing math problems and students rarely ask questions or express ideas workmanship. This study aims to determine the effect of mathematical problem
Muhamad Syazali
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Description and impact of a distance mathematics course for Grade 10 to 12 teachers

Pythagoras, 2007
This paper explores the impact of a one-year in-service distance education  mathematics  course that follows a problem-solving approach. The course aims  to develop teachers’ mathematical thinking skills.
Gerrit Stols, Alwyn Olivier, Diane Grayson   +2 more
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

ANALISIS STRATEGI MENYEDERHANAKAN MASALAH SERUPA DAN SUDUT PANDANG LAIN PADA PERMASALAHAN NON RUTIN PENJUMLAHAN FUNGSI

Aksioma: Jurnal Program Studi Pendidikan Matematika, 2017
The problem of Addition Operation of Functions often emerges in Junior National Science and Math Olympiads at the regional level, provincial level, and national level.
Kartika Maharani Dwi Astuti, Rubono Setiawan   +1 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

ASSESSING STUDENTS’ MATHEMATICAL PROBLEM-SOLVING ABILITY

Aksioma: Jurnal Program Studi Pendidikan Matematika, 2023
Students' ability to solve mathematical problems is the most important part of learning mathematics. Therefore, assessing students' ability to solve mathematical problems is one of the tasks of mathematics teachers that must be done.
Sufyani Prabawanto, Nadya Syifa Utami, Aneu Pebrianti   +2 more
doaj   +1 more source

The challenge and opportunities of quantum literacy for future education and transdisciplinary problem-solving [PDF]

, 2021
Laurentiu Nita, Laura Mazzoli Smith, Nicholas Chancellor, Helen Cramman   +3 more
openalex   +1 more source