Results 41 to 50 of about 3,105,651 (292)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Design as interactions of problem framing and problem solving [PDF]

, 2002
This paper introduces a model of framing in design. The model takes into account a reflective nature of designing, and it is based on the interplay between two conceptually distinct knowledge sources – an explicit specification of a problem and a ...
Dzbor, Martin, Zdrahal, Zdenek
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Prediction and Classification of Phenol Contents in Cnidium officinale Makino Using a Stacking Ensemble Model in Climate Change Scenarios

Agronomy
Recent studies have focused on using big-data-based machine learning to address the effects of climate change scenarios on the production and quality of medicinal plants.
Hyunjo Lee, Hyun Jung Koo, Kyeong Cheol Lee, Yoojin Song, Won-Kyun Joo, Cheol-Joo Chae   +5 more
doaj   +1 more source

Pengaruh Model Pembelajaran Creative Problem Solving Terhadap Keterampilan Pemecahan Masalah dan Hasil Belajar Kognitif Siswa

Prisma Sains: Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram, 2017
This research with the aim to know the influence of the use of Creative Problem solving learning model on problem solving skills and cognitive learning outcomes of grade X SMA Islam Al-Ma'arif Pandan Indah Lesson 2016/2017. Population in this research is
Rosmianti Lestari Mbembok, Any Fatmawati, Siti Rabiatul Adawiyah   +2 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

PENGARUH MODEL PEMBELAJARAN CREATIVE PROBLEM SOLVING BERBANTUAN MEDIA MAPLE 11 TERHADAP KEMAMPUAN PEMECAHAN MASALAH MATEMATIS

Al-Jabar, 2015
Lack of mathematical problem solving ability of students in Bandar Lampung MAN 2 due learners trouble completing math problems and students rarely ask questions or express ideas workmanship. This study aims to determine the effect of mathematical problem
Muhamad Syazali
doaj   +1 more source

Compositionality Solves Carnap’s Problem

Erkenntnis, 2015
The standard relation of logical consequence allows for non-standard interpretations of logical constants, as was shown early on by Carnap. But then how can we learn the interpretations of logical constants, if not from the rules which govern their use?
Bonnay, Denis, Westerståhl, Dag
openaire   +3 more sources

Introductory Problem Solving in Computer Science [PDF]

, 1997
This paper describes our experiences in devising a lightweight, informal methodology for problem solving in introductory, university level, computer science.
Barnes, David J., Fincher, Sally, Thompson, Simon   +2 more
core   +1 more source

Self-Affirmation Improves Problem-Solving under Stress [PDF]

, 2013
High levels of acute and chronic stress are known to impair problem-solving and creativity on a broad range of tasks. Despite this evidence, we know little about protective factors for mitigating the deleterious effects of stress on problem-solving ...
A Martens, A McQueen, A Miyake, AFT Arnsten, AM Isen, BA Nijstad, C Liston, C Liston, C Martindale, CJ Wakslak, CM Steele, CM Steele, D Watson, DK Sherman, DK Sherman, E Bowden, E Bowden, G Rowe, GL Cohen, GL Cohen, J Blascovich, J Crocker, J. David Creswell, Janine M. Dutcher, JD Creswell, JD Creswell, JK Alexander, John M. Levine, José César Perales, JP Jamieson, KS Bowers, M Jung-Beeman, Peter R. Harris, RA Dienstbier, RJ Benschop, RM Baron, S Cohen, S Cohen, S Mednick, S Sandkühler, SL Beilock, T Schmader, William M. P. Klein   +42 more
core   +3 more sources