Results 51 to 60 of about 6,229,141 (293)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Secondary School Teachers’ Perceptions about Their Problem Solving Abilities [PDF]

İnönü Üniversitesi Eğitim Fakültesi Dergisi, 2008
The purpose of the study is to determine the perceptions of high school teachers abouttheir level of problem solving skills and to find out whether their perceptions differaccording to gender, seniority, branch, marital status, how many children they ...
Hasan DEMİRTAŞ, Burhanettin DÖNMEZ
doaj  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Evaluating problem solving in the mathematics curriculum : a case study [PDF]

, 1991
The purpose of this evaluation case study was to assess the current status of problem solving in a typical mathematics curriculum, and to examine the process involved in the implementation of the recommendations found in NCTM's Standard 1: Mathematics as
Jetton, Janice H., NC DOCKS at The University of North Carolina at Greensboro   +1 more
core  

Torrance's Future Problem-Solving Instruction: Developing Students' Problem-Solving Ability

Jurnal Ilmiah Pendidikan Fisika Al-Biruni, 2020
The purpose of this research was to develop the problem-solving ability of grade 10th students by using Torrance’s future problem-solving instruction. The researchers used action research in this study.
Asanlaya Duangrawa, Prasart Nuangchalerm
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Problem solving difficulty from unrecognized equivalency [PDF]

, 2011
Equivalency occurs in problem solving when a single state can be represented by multiple configurations. If unrecognized, multiple equivalent states can be perceived as new, unique states. This confusion can hinder problem solving. Three experiments used
Leroux, Andrew L., NC DOCKS at The University of North Carolina at Greensboro   +1 more
core  

Investigation of the Solutions of Prizren-Kosovo Education Faculty Teachers Mathematics Problems

Prizren Social Science Journal, 2018
The aim of the study was to examination of mathematical problem-solving skills and to determine the relationship of between problem posing and problem-solving skills of teacher trainees in Prizren “Ukshin Hoti” University, Faculty of Education in ...
Münevver MUYO YILDIRIM, Hülya GÃœR   +1 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source