Results 51 to 60 of about 1,088,925 (306)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Problem-solving skills of futsal players with regard to some socio-demographic variables

Türk Spor ve Egzersiz Dergisi, 2017
The aim of this study is to evaluate problem-solving skills of female futsal teams that compete in the Futsal League of Turkish Universities Sports Federation in terms of some socio-demographic variables.
Musa Con, Soner Cankaya, Mehmet Yalcin Tasmekteplıgıl, Kürşat Acar   +3 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

ANALYSIS OF PERSON'S PROBLEM-SOLVING SKILLS

Prima: Jurnal Pendidikan Matematika
This research is part of the development of an essay item instrument for problem-solving skills in the Basic Mathematics Course. Measuring the ability of Mathematics problem-solving skills was carried out on 298 students of the Information Systems Study ...
Munali Munali, Hawa Liberna, Tatan Zenal Mutakin   +2 more
doaj   +1 more source

A collaborative approach to learning programming: a hybrid learning model [PDF]

, 2005
The use of cooperative working as a means of developing collaborative skills has been recognised as vital in programming education. This paper presents results obtained from preliminary work to investigate the effectiveness of Pair Programming as a ...
Ferguson, John D., Ma, Linxiao, Roper, Marc, Wilson, John, Wood, Murray   +4 more
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Influence of students' learning style and personality characteristics on their mathematics problem-solving skills

Frontiers in Education
Problem-solving skills of students are indicators of their intellectual behavior, and they determine higher-order thinking skills that students need to master.
Jonni Sitorus, Jonni Sitorus, Bornok Sinaga, Lili Handayani, Dumora Jenny Margaretha Siagian   +4 more
doaj   +1 more source

ORNE Learning Model to Improve Problem-Solving Skills of Physics Bachelor Candidates: An Alternative Learning in the Covid-19 Pandemic

Jurnal Penelitian Fisika dan Aplikasinya, 2020
In this industrial revolution 4.0 era, professional science, technology, engineering, and mathematics (STEM) bachelor must have various skills. One of which is problem-solving skills.
Binar Kurnia Prahani, Ali Hasbi Ramadani, Diah Hari Kusumawati, Nadi Suprapto, Madlazim Madlazim, Budi Jatmiko, Zainal Arifin Imam Supardi, Husni Mubarok, Shabrina Safitri, Utama Alan Deta   +9 more
doaj   +1 more source

Adaptability and problem solving as survival skills

GiLE Journal of Skills Development, 2022
This study investigates student teachers' adaptability and problem-solving abilities during their practice teaching in a school-university partnership.
Khin Khin Thant Sin
doaj   +1 more source

Sensory Substitution, Key to Inclusive Learning [PDF]

, 2020
Visually impaired students, in primary education, encounter unique challenges while learning creative skills, exploring artistic expression and developing problem-solving skills, because so much instructional content is delivered visually.
Zahir, Fathima Z
core   +1 more source