Results 51 to 60 of about 396,482 (263)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Convergent and divergent predictors of extensive use time and problematic TikTok use

Cyberpsychology: Journal of Psychosocial Research on Cyberpspace
Short videos on TikTok provided an entertaining pastime for 1.5 billion users worldwide in 2023. The increasing popularity of TikTok has generated considerable research interest in the psychological and social predictors of problematic use.
Ágnes Zsila, Mara S. Aruguete, Reza Shabahang, Ágnes Buvár, Gábor Orosz   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A Cross-Sectional Study to Assess the Problematic Use of Mobile Phones among a Selected Population in an Urban Area

Indian Journal of Psychiatric Nursing, 2019
Background: Life without a mobile phone would seem next to impossible today, where it is used not only for the sole purpose of communication but also as a storehouse of important personal information, internet facilities, navigation, social networking ...
Radhika Das, Punita A. Sharma
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

A Qualitative Analysis of Problematic and Non-problematic Alcohol Use After Bariatric Surgery [PDF]

Obesity Surgery, 2019
Bariatric surgery is an effective weight loss tool, but an under-communicated side effect may include the increased risk for alcohol problems. Few studies have examined contributors towards alcohol problems following surgery using a qualitative approach.
Reaves, DL, Dickson, JM, Halford, JCG, Christiansen, P, Hardman, CA   +4 more
openaire   +6 more sources

Family strains and online gains: Longitudinal relationship between harsh parenting and problematic internet use via relative deprivation and online basic psychological need satisfaction

Cyberpsychology: Journal of Psychosocial Research on Cyberpspace
Harsh parenting has been demonstrated as a risk factor for adolescent problematic internet use (PIU), while its relationships with distinct subtypes of PIU have been scarcely investigated.
Zongyuan Wang, Qinxue Liu, Zien Ding, Di Qi   +3 more
doaj   +1 more source