Results 51 to 60 of about 88,443,461 (253)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Self-similarity in homogeneous stationary and evolution problems

, 2023
We analyse self-similarity properties related to linear elliptic and evolutionary problems involving homogeneous operators in several spaces including measures.
Jan W. Cholewa, Rodríguez Bernal, Aníbal, Cholewa, Jan W., Anibal Rodriguez-Bernal   +3 more
core   +1 more source

Obesogens: molecular signaling pathways in fish

Frontiers in Marine Science, 2015
* santos@ciimar.up.pt; filipe.castro@ciimar.up.pt In mammals, improper control of lipid metabolism may result in serious health problems such as obesity, increased risk of coronary disease, diabetes and related problems.
Miguel Machado Santos, Mónica Marques, Luis Filipe, C Castro   +2 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Conceptos médicos en Purgatorio XXV, vv. 37-78. Las virtudes y el desarrollo vital del feto.

Cuadernos de Filología Italiana, 2007
A passage from Divina Commedia (Purgatorio XXV, vv. 37-78) is analyzed that presents different reading problems, especially those related to doctrinal and medical aspects of medieval thought.
María Clara Iglesias Rondina
doaj  

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

ON SOME OF THE SMARANDACHE'S PROBLEMS [PDF]

, 2009
The bigger part of the problems discussed in the present book (22 in number) are related to different sequences. For each of them the form of the n-th member is determined and for all of them except 4 problems - the form of the n-th partial sum.
Atanassov, T. Krassimir
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Ocular Problems Related to Television Falls in Childhood

, 2013
Television (TV) falls cause serious morbidity and mortality in children. Head trauma is frequently seen, and cranial nerve palsies ( 6th and 7th nerves are more frequently affected) are associated with head trauma. Strabismus surgery can be performed in
Yalçındağ, Fadime Nilüfer, Huban Atilla, Savku, Esra, Esra Savku, Atilla, Hüban, Fatime Nilüfer Yalçındağ   +5 more
core   +1 more source