Results 61 to 70 of about 231,053 (315)
Discussions on the disciplinary system of modern karstology
Carsologica Sinica, 2022 As an important part of modern earth science, karstology (karst science) has always been considered as a cross and marginal discipline between geology, geography, environmental science and ecology, but has not established its own independent discipline ...
Junbing PU
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Linear first-order evolution problems without initial conditions
, 2009 Direct and inverse problems for first-order in time linear evolution problems without initial conditions, i.e. related to the unbounded time interval $(-\infty,0]$, are considered in the framework of Banach spaces.
M. Bokalo, A. Lorenzi
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Obesogens: molecular signaling pathways in fish
Frontiers in Marine Science, 2015 * santos@ciimar.up.pt; filipe.castro@ciimar.up.pt In mammals, improper control of lipid metabolism may result in serious health problems such as obesity, increased risk of coronary disease, diabetes and related problems.
Miguel Machado Santos +2 more
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FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Energy-Minimizing Microstructures in Multiphase Elastic Solids [PDF]
, 2004 This thesis concerns problems of microstructure and its macroscopic consequences in multiphase elastic solids, both single crystals and polycrystals. The elastic energy of a two-phase solid is a function of its microstructure.
Chenchiah, Isaac Vikram
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FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Conceptos médicos en Purgatorio XXV, vv. 37-78. Las virtudes y el desarrollo vital del feto.
Cuadernos de Filología Italiana, 2007 A passage from Divina Commedia (Purgatorio XXV, vv. 37-78) is analyzed that presents different reading problems, especially those related to doctrinal and medical aspects of medieval thought.
María Clara Iglesias Rondina
doaj
Variational satisfiability solving: efficiently solving lots of related SAT problems
, 2022 Incremental satisfiability (SAT) solving is an extension of classic SAT solving that enables solving a set of related SAT problems by identifying and exploiting shared terms.
Bittner, Paul Maximilian +3 more
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