Results 61 to 70 of about 88,443,461 (253)
Requirements evolution: from assumptions to reality [PDF]
, 2011 . Requirements evolution is a main driver for systems evolution. Tradi-tionally, requirements evolution is associated to changes in the users ’ needs and environments.
Vı́tor E. Silva Souza +13 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Direct and inverse problems related to MEMS
, 2009 This paper deals with direct and inverse evolution problems which come up in studying micro-electro-mechanical-systems: here we consider a nonlinear and nonlocal MEMS model.
A. Lorenzi +3 more
core +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
Diagnosing Problems - Raw Materials
, 2011 The raw materials which make up the Diagnosing Problems learning activity which introduces the concept of problem diagnosis and offers techniques and tools to find problem causes.
EVOLUTION +4 more
core
Language learning strategies used by undergraduates to overcome language and affective-related problems in speaking English / Hazlia Azila Illias [PDF]
, 2012 A study was carried out to examine and to compare between the perceptions of the English-major and non-English-major University of Malaya students towards the problems they faced in speaking English and between the strategies they used to improve ...
Hazlia Azila, Illias
core
The provincial development according to governor's order of 1837
RUDN Journal of Law, 2008 The thesis is devoted to the evolution of the governor's institute in the Russian empire. The article is focused on the problems related to formation and development of governor's institute according to Governor's order of 1837.
S A Alekseev, Ts Ts Mihkeeva
doaj
Legacy of Ludwig von Mises: Rationalism
Studies in Logic, Grammar and Rhetoric, 2019 There are three intentions (aims) of this paper. First, to focus the attention of readers to three not so well known and least frequently quoted by economists of Mises’s books, namely his 1957 Theory and History: An Interpretation of Social and Economic ...
Kwasnicki Witold
doaj +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source