Results 41 to 50 of about 10,100 (267)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Peri-procedural management of patients with cardiac implantable electrical devices. Guidelines by the Working Group on Cardiac Arrhythmias and Pacing of the Hungarian Society of Cardiology for anaesthesiologists and for professionals in surgical fields and emergency care

Cardiologia Hungarica
The peri-procedural management of the increasing number of patients living with cardiac implantable electronic devices (such as pacemakers or implantable cardioverter-defibrillators) presents a growing burden for electrophysiologists, anesthesiologists ...
Gábor Sándorfi, Márton Miklós, Annamária Kosztin, István Osztheimer, Nándor Szegedi, Péter Kupó, Gábor Zoltán Duray, Előd János Zsigmond, László Gellér, Csaba Földesi, Endre Zima, Vámos Máté   +11 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Relational and Object-Oriented Methodology in Data Bases Systems [PDF]

Informatică economică, 2006
Database programming languages integrate concepts of databases and programming languages to provide both implementation tools for data-intensive applications and high-level user interfaces to databases.
Marian Pompiliu CRISTESCU, Gabriel SOFONEA, Eugen COJOCARIU   +2 more
doaj  

Awkward Just-In-Time (JIT) Compilation: A Developer’s Experience [PDF]

EPJ Web of Conferences
Awkward Array is a library for performing NumPy-like computations on nested, variable-sized data, enabling array-oriented programming on arbitrary data structures in Python.
Osborne Ianna, Pivarski Jim, Ifrim Ioana, Hollands Angus, Schreiner Henry   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

ECOLE: a pedagogical environment for non procedural languages

Journal of Computer Science and Technology, 2007
The work described in this paper is related to three areas in the programming world : logic, functional and object programming. The main objective is essentially pedagogical since it is question here to make a synthesis on non procedural languages.
D. E. Zegour, W. K. Hidouci
doaj  

An Experimental Study to Evaluate the Impact of the Programming Paradigm in the Testing Activity

CLEI Electronic Journal, 2012
Several techniques and criteria are available to help conducting testing activity. The choice for one of them depends on different aspects, such as the time restrictions, ef- fectiveness of the testing criteria or the features of the program under test ...
Simone de Rocio Senger de Souza, Marllos Paiva Prado, Ellen Francine Barbosa, José Carlos Maldonado   +3 more
doaj   +1 more source

Java problem-based learning [PDF]

Vojnotehnički Glasnik, 2012
The paper describes the self-directed problem-based learning system (PBL) named Java PBL. The expert module is the kernel of Java PBL. It involves a specific domain model, a problem generator and a solution generator.
Goran P, Šimić
doaj   +1 more source