Results 61 to 70 of about 3,706,736 (294)

Procedural Modeling for Digital Cultural Heritage

EURASIP Journal on Image and Video Processing, 2009
The rapid development of computer graphics and imaging provides the modern archeologist with several tools to realistically model and visualize archeological sites in 3D. This, however, creates a tension between veridical and realistic modeling. Visually
Simon Haegler, Luc Van Gool, Pascal Müller   +2 more
doaj   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

AI Neutrality in Title IX Investigations and Decision-Making within Higher Education

The Pinnacle
Algorithmic tools are being increasingly used to support administrative and quasi-judicial decision-making processes. As such, higher education institutions are beginning to explore algorithmic tools to organize case materials, conduct interviews ...
Jason Everson
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

A study of Chinese law on restricting personal liberty for public health protection: taking the COVID-19 epidemic as the entry point

Frontiers in Public Health
During the COVID-19 pandemic, China adopted restrictive measures such as mandatory quarantine, health code management, and community lockdowns. These actions were effective in containing the epidemic but often lacked clear legal authorization or ...
Tengfei Liu, Zhongwu Ma
doaj   +1 more source

Cartwright's Theorem and Procedural Approach to Causality [PDF]

, 2004
N. Cartwright's recent results on invariance under intervention and causality (2003) are reconsidered. Procedural approach to causality elicited in this paper and contrasted with Cartwright's apparently philosophical one unravels certain ramifications of
Kawalec, Pawel
core  

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Procedural Pain and Situational Anxiety in Pediatric Patients: A Narrative Review of Assessment Tools

Pediatric Reports
Background: Procedural pain and anxiety are common phenomena among children hospitalized in pediatric wards; however, they are often under-recognized. These experiences frequently accompany patients during various diagnostic and therapeutic procedures ...
Anna Wojciechowska-Urbanek, Jowita Rosada-Kurasińska, Alicja Bartkowska-Śniatkowska   +2 more
doaj   +1 more source