Results 81 to 90 of about 7,411,622 (289)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Cartwright's Theorem and Procedural Approach to Causality [PDF]

open access: yes, 2004
N. Cartwright's recent results on invariance under intervention and causality (2003) are reconsidered. Procedural approach to causality elicited in this paper and contrasted with Cartwright's apparently philosophical one unravels certain ramifications of
Kawalec, Pawel
core  

Lifting the understanding of trigonometric limits from a procedural towards a conceptual understanding

open access: yes, 2021
The purpose of this paper is to follow the reasoning of high school students when asked to explain the standard trigonometric limit    . An observational study was conducted in four different phases in order to investigate if visualization, by means of ...
Cortas Nordlander, Maria   +2 more
core   +1 more source

Procedural Effects of Court Settlements

open access: yesLaw & Criminology Journal
Court settlements, that is, settlements concluded by the parties to a pending action and registered by the court to render procedural effects upon them, are common in many European jurisdictions.
Anna Nylund
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Mathematics Teachers' Understanding of the Algorithms for Solving Quadratic Function Problems

open access: yesHipotenusa
This study investigated secondary school mathematics teachers' understanding of the mathematical concepts underlying the algorithms used in teaching quadratic functions.
Emmanuel Ibeawuchi, Ugorji Ogbonnaya
doaj   +1 more source

Probleme teoretico-practice la căutărea paratului in cadrul procesului civil [PDF]

open access: yesRevista Institutului Naţional de Justiţie, 2016
„Search of the defendant” represents an important procedural guarantee established by the legislator in favor of the defendant. Inconsideration of such a guarantee may have important procedural repercussions, even being a reason for quashing a court ...
Moscalciuc Vitalie, Creţu Vasile
doaj  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

A Practical View on Procedural Generation: Benefits, Capabilities, and Usability

open access: yesIEEE Access
Procedural generation is widely applied, from accelerating development of large and detailed virtual worlds to providing highly varied game content during gameplay.
Robert Andrei Caragicu   +3 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

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