Results 161 to 170 of about 11,037,570 (334)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Therapeutic Procedures and Use of Alternating Antipyretic Drugs for Fever Management in Children

open access: gold, 2013
Gracian Li Pereira   +3 more
openalex   +1 more source

Combined transhepatic and endoscopic procedures in the biliary system [PDF]

open access: bronze, 1993
Anthony Verstandig   +6 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Establishing monthly cardiac arrest simulation in the Regional Day Procedure Centre

open access: yesBJA Open
J.T. Kennedy   +6 more
doaj   +1 more source

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