Results 61 to 70 of about 481,160 (254)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Reformas al derecho canónico procesal propuestas por los metropolitanos españoles al iniciarse la codificación canónica de 1917

open access: yesVergentis. Revista de Investigación de la Cátedra Internacional Conjunta Inocencio III, 2018
The drafting of the first Code of Canon Law of the Latin Catholic Church was ordered by Pope Saint Pius X in 1904. The code was not made by a close group of experts, but considered the opinion of the whole episcopate. Such an opinion was consulted in two
Carlos René Salinas Araneda
doaj  

Right of Public Concerned to a Favourable Environment in the Slovak Republic [PDF]

open access: yesSocietas et Iurisprudentia, 2015
The paper analyses changes and development in the field of legal status of the public within the environmental impact assessment. The Act No. 314/2014 Coll. amending and supplementing the Act No. 24/2006 Coll.
Michal Maslen
doaj  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Report on Proceedings of the Sixth Annual Meeting of the European CME Forum, London, UK, 14–15 November 2013

open access: yesJournal of European CME, 2014
Delegates from around the world attended the sixth annual meeting of the European CME Forum in London between 14 and 15 November 2013. The participants discussed best practices in continuing medical education and continuing professional development (CME ...
Ron Murray
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Establishment of specialist commercial courts in the State of Qatar: A comparative study

open access: yesInternational Review of Law, 2016
The social and economic progress witnessed in Qatar, similar to other countries in the world, has led to the emergence of commercial transactions that were not previously known, thus the need for establishing specialist commercial courts to address ...
Mohammed Abdulaziz Al-Khulaifi   +1 more
doaj   +2 more sources

Ankara Papers in Turkish and Turkic Linguistics. Edited by Deniz Zeyrek, Çiğdem Sağın Şimşek, Ufuk Ataş, and Jochen Rehbein.

open access: yesDilbilim Araştırmaları Dergisi, 2016
Review of the proceedings of 16th International Conference on Turkish Linguistics (ICTL) held in METU at 18-21 September, 2012.
Aslı Gürer
doaj  

Home - About - Disclaimer - Privacy