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Challenges and Opportunities of Implementing Data Fusion in Process Analytical Technology—A Review [PDF]
Molecules, 2022 The release of the FDA’s guidance on Process Analytical Technology has motivated and supported the pharmaceutical industry to deliver consistent quality medicine by acquiring a deeper understanding of the product performance and process interplay.
Tibor Casian +5 more
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A FT-NIR Process Analytical Technology Approach for Milk Renneting Control [PDF]
Foods, 2021 The study proposes a process analytical technology (PAT) approach for the control of milk coagulation through near infrared spectroscopy (NIRS), computing multivariate statistical process control (MSPC) charts, based on principal component analysis (PCA).
Silvia Grassi +5 more
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Editorial: Freeze-Drying and Process Analytical Technology for Pharmaceuticals [PDF]
Frontiers in Chemistry, 2018 Davide Fissore, Timothy McCoy
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A NIR-Based Study of Desorption Kinetics during Continuous Spin Freeze-Drying
Pharmaceutics, 2021 The pharmaceutical industry is progressing toward the development of more continuous manufacturing techniques. At the same time, the industry is striving toward more process understanding and improved process control, which requires the implementation of
Laurens Leys +6 more
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Gas Antisolvent Approach for the Precipitation of α -Methoxyphenylacetic Acid – ( R )-1-Cyclohexylethylamine Diateromeric Salt [PDF]
Chemical and Biochemical Engineering Quarterly, 2017 One of the major drawbacks of diastereomeric salt precipitation based enantioseparation is the time and solvent requirement of crystallization. In the gas antisolvent (GAS) approach, supercritical carbon dioxide is applied as an antisolvent, and the ...
A. Zodge +6 more
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Scientific Reports, 2023 The osteochondral interface is a thin layer that connects hyaline cartilage to subchondral bone. Subcellular elemental distribution can be visualised using synchrotron X-ray fluorescence microscopy (SR-XFM) (1 μm).
Xiwei Fan +6 more
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C, 2022 Storage is still limiting the implementation of hydrogen as an energy carrier to integrate the intermittent operation of renewable energy sources.
Jose A. Villajos
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Spin Freezing and Its Impact on Pore Size, Tortuosity and Solid State
Pharmaceutics, 2021 Spin freeze-drying, as a part of a continuous freeze-drying technology, is associated with a much higher drying rate and a higher level of process control in comparison with batch freeze-drying.
Joris Lammens +7 more
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Model-based optimization of the primary drying phase of oral lyophilizates
International Journal of Pharmaceutics: X, 2020 Oral lyophilizates also called orally disintegrating tablets (ODTs) are a patient friendly and convenient dosage form. They are manufactured by dosing a suspension in blister cups and subsequently freeze-drying these blisters to achieve porous tablets ...
Brecht Vanbillemont, Thomas De Beer
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Antibody Concentration Measurement Using Optical Rotation: Toward Process Analytical Technology [PDF]
MATEC Web of Conferences, 2021 The antibody manufacturing process consists of the cell culture process using animal cells and the purification process including several chromatography steps and filtration steps.
Inaba Hidenori +4 more
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