Cogeneration Technology Alternatives Study (CTAS). Volume 2: Analytical approach [PDF]
The use of various advanced energy conversion systems were compared with each other and with current technology systems for their savings in fuel energy, costs, and emissions in individual plants and on a national level.
Brown, D. H. +4 more
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
On the Use of Temperature Measurements as a Process Analytical Technology (PAT) for the Monitoring of a Pharmaceutical Freeze-Drying Process. [PDF]
Pharmaceutics, 2023 Vallan A +3 more
europepmc +1 more source
Process analytical technology for continuous manufacturing of solid-dosage forms [PDF]
, 2015 De Beer, Thomas +6 more
core +1 more source
Transformation of the Family under Rising Land Pressure: A Theoretical Essay [PDF]
If we understand well the individualization of land tenure rules under conditions of growing land scarcity and increased market integration, much less is known about the mode of evolution of the farm-cum-family units possessing the land.
Catherine Guirkinger +1 more
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Machine learning and metabolic modelling assisted implementation of a novel process analytical technology in cell and gene therapy manufacturing. [PDF]
Sci Rep, 2023 Williams T +11 more
europepmc +1 more source
Systematization of Methods and Modern Technologies of Interrelations Between Banks and Clients Management in Ukraine [PDF]
, 2016 Interrelations with clients are the basis of banking system functioning. But in the process of attracting new customers banks should pay attention to avoiding high credit risk and money laundering risk.
Kolodiziev, O. (Oleh) +1 more
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source