Results 111 to 120 of about 1,866,340 (300)

A Bioreactor-Based Yellow Fever Virus-like Particle Production Process with Integrated Process Analytical Technology Based on Transient Transfection. [PDF]

Viruses, 2023
Dekevic G, Tertel T, Tasto L, Schmidt D, Giebel B, Czermak P, Salzig D.   +6 more
europepmc   +1 more source

Analytic Hierarchy Process: Automobile Steering Technology

International Journal of Engineering and Advanced Technology, 2019
The Analytic Hierarchy Process (AHP) is a well-liked multi-criteria decision making method. In current research an attempted has been made by researcher to present an application of the AHP. It is used to find the weightages of the selected factors for the automobile steering technology.
Rajnish Katarne*, Jayant Negi
openaire   +1 more source

Transformation of the Family under Rising Land Pressure: A Theoretical Essay [PDF]

If we understand well the individualization of land tenure rules under conditions of growing land scarcity and increased market integration, much less is known about the mode of evolution of the farm-cum-family units possessing the land.
Catherine Guirkinger, Jean-Philippe Platteau   +1 more
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

On the Use of Temperature Measurements as a Process Analytical Technology (PAT) for the Monitoring of a Pharmaceutical Freeze-Drying Process. [PDF]

Pharmaceutics, 2023
Vallan A, Fissore D, Pisano R, Barresi AA.   +3 more
europepmc   +1 more source

Process Analytical Technologies in Biopharmaceutical Process Development [PDF]

Journal of Chemical Technology & Biotechnology, 2015
Rathore, Anurag S., Gernaey, Krist V., Calado, Cecília R. C., Yoon, Seongkyu   +3 more
openaire   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Machine learning and metabolic modelling assisted implementation of a novel process analytical technology in cell and gene therapy manufacturing. [PDF]

Sci Rep, 2023
Williams T, Kalinka K, Sanches R, Blanchard-Emmerson G, Watts S, Davies L, Knevelman C, McCloskey L, Jones P, Mitrophanous K, Miskin J, Dikicioglu D.   +11 more
europepmc   +1 more source

Process analytical technology for continuous manufacturing of solid-dosage forms [PDF]

, 2015
De Beer, Thomas, De Leersnyder, Fien, Fonteyne, Margot, Remon, Jean Paul, Van Snick, Bernd, Vercruysse, Jurgen, Vervaet, Chris   +6 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source