Results 111 to 120 of about 5,516 (293)

Introducing process analytical technology (PAT) in filamentous cultivation process development: comparison of advanced online sensors for biomass measurement

open access: yes, 2011
The recent process analytical technology (PAT) initiative has put an increased focus on online sensors to generate process-relevant information in real time.
Stocks, Stuart M.   +7 more
core   +1 more source

Electrode and Microstructure Dependence of Oxygen Diffusion in Ferroelectric Hafnium Zirconium Oxide Thin Films

open access: yesAdvanced Functional Materials, EarlyView.
Significant nanoscale oxygen diffusion coefficient variations are measured in ferroelectric hafnium zirconium oxide films with grain boundaries and electrode interfaces exhibiting values 104 times larger than the grain cores. Overall coefficients are 10X larger for films prepared with metal nitride electrodes compared to refractory metals. New insights
Liron Shvilberg   +6 more
wiley   +1 more source

The Current Status of Process Analytical Technologies in the Dairy Industry

open access: yes, 2015
The term Process Analytical Technology (PAT) is now popular in the chemical, food and pharmaceutical industries, collectively representing instruments, methods and strategies to provide a timely analysis of critical quality parameters to improve product ...
Yu, Wei   +3 more
core   +1 more source

Historical Foundation and Practical Guideline for Ferroelectric Switching Kinetic Studies

open access: yesAdvanced Functional Materials, EarlyView.
The P and U pulses in the conventional PUND measurements are not identical because of the interplay between switching current and the measurement circuit components. This circuit effect can lead to a shift in polarization transients and misinterpreted physics in the switching kinetics.
Yi Liang, Pat Kezer, John T. Heron
wiley   +1 more source

Bioprocess monitoring applications of an innovative ATR-FTIR spectroscopy platform

open access: yesFrontiers in Bioengineering and Biotechnology
Pharmaceutical manufacturing is reliant upon bioprocessing approaches to generate the range of therapeutic products that are available today. The high cost of production, susceptibility to process failure, and requirement to achieve consistent, high ...
Loren Christie   +7 more
doaj   +1 more source

Development of a process analytical technology (PAT) infrastructure for future biologics upstream processing

open access: yes, 2016
Process Analytical Technology (PAT) involves the timely analysis of Critical Quality Attributes (CQAs) and Critical Process Parameters (CPPs) with the aim to improve the process control strategy resulting in a better process performance and robust ...
Steefland, Mathieu
core  

Maximizing viral titer yield at harvest through metabolic process analytical technology (PAT)

open access: yes, 2022
This work pertains to the optimization of enterovirus production using MRC5 cultured on microcarriers within a bioreactor. This enterovirus, like other lytic viruses, has a rapid decay rate within a production batch, such that a 30% loss of potency is ...
Templeton, Neil   +3 more
core  

Exciton Binding Energy of Phosphorescent Emitter Molecules in Organic Light‐Emitting Diodes

open access: yesAdvanced Functional Materials, EarlyView.
Energy level alignment is key to efficient OLED design, yet determining LUMO energies remains challenging. A methodology based on field‐induced dissociation and kinetic Monte Carlo simulations is presented to extract LUMO energies of iridium‐based phosphorescent emitters from their exciton binding energy.
Hiroki Tomita   +6 more
wiley   +1 more source

Enhancing Process Control and Quality in Amorphous Solid Dispersions Using In-Line UV–Vis Monitoring of L* as a Real-Time Response

open access: yesPharmaceutics
Background: This study demonstrates the application of the sequential design of experiments (DoE) approach within the quality by design (QbD) framework to optimize extrusion processes through screening, optimization, and robustness testing.
Mariana Bezerra   +4 more
doaj   +1 more source

Analysis and critical review of ICH Q8, Q9 and Q10 from a generic pharmaceutical industry view point [PDF]

open access: yesMakedonsko Farmacevtski Bilten, 2012
Generic industry aims to produce safe, efficient, built-in quality medicines that will satisfy patients’ requirements and will be competitive on the market.
Ljuba Karanakov   +3 more
doaj  

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