Results 91 to 100 of about 129,506 (299)

A compact microflow liquid chromatography system for at-sample reaction monitoring of pharmaceutical active ingredient synthesis

Journal of Pharmaceutical and Biomedical Analysis Open
Process analytical technology (PAT) and real-time release testing (RTRT) are transforming pharmaceutical manufacturing by enabling continuous quality assurance through real-time process data rather than traditional end-product testing.
Shing Chung Lam, Penelope Huggins, Shanmugapriya Vasudevan, Boyjie Firme, Laell Raiteri, Andrew A. Gooley   +5 more
doaj   +1 more source

Establishment of a continuous sonocrystallization process for lactose in an oscillatory baffled crystallizer [PDF]

, 2015
Crystallization at production scale (>10 kg) is typically a poorly understood unit operation with limited application of first-principles understanding of crystallization to routine design, optimization, and control.
Brown, Cameron J., Florence, Alastair J., Houson, Ian, Siddique, Humera   +3 more
core   +2 more sources

An Application of X-Ray Fluorescence as Process Analytical Technology (PAT) to Monitor Particle Coating Processes

Chemical and Pharmaceutical Bulletin, 2018
An attempt to apply X-Ray Fluorescence (XRF) analysis to evaluate small particle coating process as a Process Analytical Technologies (PAT) was made. The XRF analysis was used to monitor coating level in small particle coating process with at-line manner. The small particle coating process usually consists of multiple coating processes.
Yoshio, Nakano, Yoshimitsu, Katakuse, Yasutaka, Azechi   +2 more
openaire   +3 more sources

Characterization of Nitinol Produced by Laser Powder Bed Fusion for Mechanical Metamaterial Applications

Advanced Engineering Materials, EarlyView.
Stabilization of L‐PBF Ni50.7Ti49.3 under low‐cycle loading was investigated. Recoverable strain after cycling was dependent on the amount of applied load. Recovery ratio was 53.4% and 35.1% at intermediate and high load, respectively. The maximum total strain reached 10.3% at a high load of 1200 MPa.
Ondřej Červinek, Jakub Hurník, Miroslav Šmíd, Ondřej Zobač, Melanie Todt, Daniel Koutný   +5 more
wiley   +1 more source

Analytical Quality by Design: A Tool for Regulatory Flexibility and Robust Analytics

International Journal of Analytical Chemistry, 2015
Very recently, Food and Drug Administration (FDA) has approved a few new drug applications (NDA) with regulatory flexibility for quality by design (QbD) based analytical approach.
Ramalingam Peraman, Kalva Bhadraya, Yiragamreddy Padmanabha Reddy   +2 more
doaj   +1 more source

First GIS analysis of modern stone tools used by wild chimpanzees (Pan troglodytes verus) in Bossou, Guinea, West Africa [PDF]

, 2015
Stone tool use by wild chimpanzees of West Africa offers a unique opportunity to explore the evolutionary roots of technology during human evolution. However, detailed analyses of chimpanzee stone artifacts are still lacking, thus precluding a comparison
Arroyo, Adrian, Benito-Calvo, Alfonso, Carvalho, Susana, de la Torre, Ignacio, Matsuzawa, Tetsuro   +4 more
core   +5 more sources

Handbook of Establishing and Maintaining Oxygen‐Free Atmospheres

Advanced Engineering Materials, EarlyView.
This study presents a practical framework for creating oxygen‐free atmospheres at ambient pressure using silane‐doped inert gases. The results show that ultra‐low oxygen levels and strongly reduced water content can be achieved through controlled silane dosing, drying systems, and sensor monitoring.
Sascha Jan Zimmermann, René Gustus, Lienhard Wegewitz, Wolfgang Maus‐Friedrichs   +3 more
wiley   +1 more source

Additive manufacturing of prototype elements with process interfaces for continuously operating manufacturing lines

Asian Journal of Pharmaceutical Sciences, 2018
Rapid prototyping based on in silico design and 3D printing enables fast customization of complex geometries to multiple needs. This study utilizes, additive manufacturing for rapid prototyping of elements for continuously operating mixing geometries ...
Cosima Hirschberg, Mikkel Schmidt Larsen, Johan Peter Bøtker, Jukka Rantanen   +3 more
doaj   +1 more source

Additive Gaussian Process Regression for Predictive Design of High‐Performance, Printable Silicones

Advanced Engineering Materials, EarlyView.
A chemistry‐aware design framework for tuning printable polydimethylsiloxane (PDMS) for vat photopolymerization (VPP) is developed using additive Gaussian process (GP) modeling. Polymer network mechanics informs variable groupings, feasible formulation constraints, and interaction variables.
Roxana Carbonell, Martha Leach, Hongtao Song, Carolyn Seepersad   +3 more
wiley   +1 more source

Development of a novel disposable flowcell for spectroscopic bioprocess monitoring

Measurement: Sensors
Regulatory authorities require product control for market release, especially for medical products due to legal regulations. Thus, end product control is conducted before drug market release.
Phil Thiel, Tobias Steinwedel, Philipp Raithel, Mathias Belz, Dörte Solle   +4 more
doaj   +1 more source