Results 71 to 80 of about 129,506 (299)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Applications of Digital Twins in Biological Industries: An Overview with a Case Study on Fed-Batch Monitoring of Pichia Pastoris Fermentation [PDF]

Iranian Journal of Chemistry & Chemical Engineering
Digital Twins (DTs) are digital representations of physical assets. DTs have emerged as a revolutionary concept in the field of biomanufacturing, offering virtual replicas of physical systems that enable comprehensive monitoring, analysis, and ...
Hossein Rahimi Jafari, Mohammad Fakhroleslam, Seyed Abbas Shojaosadati   +2 more
doaj   +1 more source

Optimal column layout for hybrid workloads [PDF]

, 2019
Data-intensive analytical applications need to support both efficient reads and writes. However, what is usually a good data layout for an update-heavy workload, is not well-suited for a read-mostly one and vice versa. Modern analytical data systems rely
Athanassoulis, Manoussos, Bøgh, Kenneth, Idreos, Stratos   +2 more
core   +1 more source

Process analytical technology (PAT) tools for the cultivation step in biopharmaceutical production

Engineering in Life Sciences, 2013
The process analytical technology (PAT) initiative is now 10 years old. This has resulted in the development of many tools and software packages dedicated to PAT application on pharmaceutical processes. However, most applications are restricted to small molecule drugs, mainly for the relatively simple process steps like drying or tableting where only a
Streefland, M., Martens, D.E., Beuvery, E.C., Wijffels, R.H.   +3 more
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Titanium alloy stress corrosion cracking in presence of dinitrogen tetroxide [PDF]

, 1972
Study resulting in a satisfactory stress corrosion cracking test with extremely consistent results produced six new analytical methods. Methods detect and determine differences in the minor constituent composition of different types of dinitrogen ...
Clarke, J. F. G., Jr., Conner, A. Z., Gailey, J. A., Orr, A. A.   +3 more
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

PROCESS ANALYTICAL TECHNOLOGY (PAT) IN PHARMACEUTICAL MANUFACTURING: A REVIEW

EPRA International Journal of Research & Development (IJRD)
Process Analytical Technology (PAT) is a key concept in pharmaceutical manufacturing that involves the use of analytical techniques to monitor and control manufacturing processes in real-time. This review aims to provide an overview of PAT in pharmaceutical manufacturing, including its principles, applications, and benefits.
null Sanjay Saravaiya, null Mohammad Kojar, null Bilal Shaikh, null Priyanshu Upadhyay   +3 more
openaire   +1 more source