Results 71 to 80 of about 18,920,531 (281)

Chemometrics-based process analytical technology (PAT) tools: Applications and adaptation in pharmaceutical and biopharmaceutical industries

, 2013
Process analytical technology (PAT) is used to monitor and control critical process parameters in raw materials and in-process products to maintain the critical quality attributes and build quality into the product.
Potumarthi, R., Challa, S.
core   +1 more source

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

Process Analytical Technology

, 2013
The term “process analytical technology” (PAT) has been used to describe the application of analytical chemistry and process chemistry combined with the multivariate tools for process understanding. PAT is a wide and complex theme, making it difficult to
Silva, João S., Martins, R., Vicente, A. A., Silva, F., Teixeira, J. A.   +4 more
core   +1 more source

Quantitative MRI Uncovers Subtle Cortical Damage in Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Valentina Camera, Agnese Tamanti, Silvia Messina, Nicola Dall'Osto, Teresa Maltempo, Stefano Ziccardi, Matteo Foschi, Maria Grazia Piscaglia, Diana Ferraro, Francesco Crescenzo, Francesca Rossi, Albulena Bajrami, Sabrina Marangoni, Damiano Marastoni, Francesca Benedetta Pizzini, Maria Isabel Leite, Roberta Magliozzi, Patrick Waters, Massimiliano Calabrese, Jacqueline Palace, Ruth Geraldes   +20 more
wiley   +1 more source

Designing Robust Process Analytical Technology (PAT) Systems for Crystallization Processes: A Potassium Dichromate Crystallization Case Study [PDF]

, 2013
The objective of this study is to test and validate a Process Analytical Technology (PAT) system design on a potassium dichromate crystallization process in the presence of input uncertainties using uncertainty and sensitivity analysis.
Sin, Gürkan, Abdul Samad, Noor Asma Fazli Bin   +1 more
core  

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif, Diane Demailly, Gabriella A. Horvàth, Juan Dario Ortigoza Escobar, Nathalie Dorison, Mayté Castro Jiménez, Cécile A. Hubsch, Thomas Wirth, Gun‐Marie Hariz, Sophie Huby, Morgan Dornadic, Zohra Souei, Muhammad Mushhood Ur Rehman, Simone Hemm, Mehdi Boulaymen, Eduardo M. Moraud, Jocelyne Bloch, Xavier Vasques   +17 more
wiley   +1 more source

Applications of Digital Twins in Biological Industries: An Overview with a Case Study on Fed-Batch Monitoring of Pichia Pastoris Fermentation [PDF]

Iranian Journal of Chemistry & Chemical Engineering
Digital Twins (DTs) are digital representations of physical assets. DTs have emerged as a revolutionary concept in the field of biomanufacturing, offering virtual replicas of physical systems that enable comprehensive monitoring, analysis, and ...
Hossein Rahimi Jafari, Mohammad Fakhroleslam, Seyed Abbas Shojaosadati   +2 more
doaj   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Leveraging Microwaves as a Process Analytical Technology (PAT) Tool in the Pharmaceutical Industry

Acta Poloniae Pharmaceutica - Drug Research
To ensure product quality and consistency, as well as compliance with regulatory standards, the pharmaceutical industry has turned to innovative solutions. One such solution is Process Analytical Technology (PAT), which has the potential to transform pharmaceutical manufacturing by enabling real-time monitoring and control of critical parameters and ...
Mateusz Mróz, Małgorzata Sznitowska
openaire   +1 more source

Posterior Disconnection Syndrome in Early‐Stage Adult‐Onset Cerebral Adrenoleukodystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adult‐onset cerebral adrenoleukodystrophy is potentially treatable but often difficult to recognize before advanced cerebral involvement. Herein, we describe three men with early‐stage disease who initially presented with subtle visual complaints rather than subcortical dementia. Targeted neuropsychological testing revealed higher‐order visual
Kazuto Katsuse, Takashi Matsukawa, Yumiko Nakamura, Kazuo Kakinuma, Shoko Ota, Ryo Hara, Saki Nakashima, Kaoru Ito, Yutaro Nakamori, Toshiyuki Kakumoto, Masashi Hamada, Shigenori Kanno, Kyoko Suzuki, Tatsushi Toda   +13 more
wiley   +1 more source