Results 61 to 70 of about 18,920,531 (281)

Process analytical technology tools for perfusion cell culture

Engineering in Life Sciences, 2016
During cell cultivation processes for the production of biopharmaceuticals, good process performance and good product quality can be ensured by online monitoring of critical process parameters (e.g. temperature, pH, or dissolved oxygen).
Sarah M. Mercier, Perrine M. Rouel, Pierre Lebrun, Bas Diepenbroek, René H. Wijffels, Mathieu Streefland   +5 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

PROCESS ANALYTICAL TECHNOLOGY (PAT) IN PHARMACEUTICAL MANUFACTURING: A REVIEW

EPRA International Journal of Research & Development (IJRD)
Process Analytical Technology (PAT) is a key concept in pharmaceutical manufacturing that involves the use of analytical techniques to monitor and control manufacturing processes in real-time. This review aims to provide an overview of PAT in pharmaceutical manufacturing, including its principles, applications, and benefits.
null Sanjay Saravaiya, null Mohammad Kojar, null Bilal Shaikh, null Priyanshu Upadhyay   +3 more
openaire   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Barriers to implementing process analytical technology in keg cleaning: a multi-stakeholder qualitative study in the brewing industry

International Journal of Sustainable Engineering
Keg cleaning is essential for hygiene but requires substantial water, energy, and chemicals. Process analytical technology (PAT) could adapt cleaning to actual contamination levels.
Fabian Kost, Peter Burggräf, Alexander Becher, Philipp Nettesheim   +3 more
doaj   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Process Analytical Technology in biopharmaceutical manufacturing [PDF]

, 2013
Thesis (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management; and, (S.M.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering; in conjunction with the Leaders for Global Operations Program at MIT, 2013.This ...
Cosby, Samuel T. (Samuel Thomas)
core  

Integration of Serum Neurofilament Light Chain and Cortical Dysfunction Improves Diagnostic Accuracy in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether integration of serum neurofilament light chain (NfL) and cortical dysfunction improves diagnostic accuracy in amyotrophic lateral sclerosis (ALS) when applied alongside the Gold Coast criteria (GCC). Methods In this prospective study, 148 participants with suspected ALS were recruited (101 ALS and 47 with ALS ...
Aicee Dawn Calma, Nathan Pavey, Yukiko Tsuji, Amirul Ab Ghapar, Mehdi A.J. van den Bos, Bronwen Orden, Grace Lee, Linda Mekhael, Julie Ryder, Cláudia Santos Silva, David McDonald, Fakhria Kakar, Con Yiannikas, Matthew C. Kiernan, David A. Brown, Parvathi Menon, Steve Vucic   +16 more
wiley   +1 more source

Artificial intelligence assisted pharmaceutical analysis for sustainable quality monitoring and continuous manufacturing applications

Discover Artificial Intelligence
Background Pharmaceutical analysis is undergoing substantial transformation through artificial intelligence (AI), machine learning (ML), Process Analytical Technology (PAT), and sustainable analytical approaches.
Annasaheb S. Gaikwad, Sonali B. Pawar
doaj   +1 more source

Aluminum Phosphate Vaccine Adjuvant: Analysis of Composition and Size Using Off-Line and In-Line Tools

Computational and Structural Biotechnology Journal, 2019
Purpose: Aluminum-based adjuvants including aluminum phosphate (AlPO4) are commonly used in many human vaccines to enhance immune response. The interaction between the antigen and adjuvant, including the physical adsorption of antigen, may play a role in
Carmen Mei, Sasmit Deshmukh, James Cronin, Shuxin Cong, Daniel Chapman, Nicole Lazaris, Liliana Sampaleanu, Ulrich Schacht, Katherine Drolet-Vives, Moriam Ore, Sylvie Morin, Bruce Carpick, Matthew Balmer, Marina Kirkitadze   +13 more
doaj   +1 more source