Results 51 to 60 of about 129,506 (299)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Process analytical technology tools for perfusion cell culture

Engineering in Life Sciences, 2016
During cell cultivation processes for the production of biopharmaceuticals, good process performance and good product quality can be ensured by online monitoring of critical process parameters (e.g. temperature, pH, or dissolved oxygen).
Sarah M. Mercier, Perrine M. Rouel, Pierre Lebrun, Bas Diepenbroek, René H. Wijffels, Mathieu Streefland   +5 more
doaj   +1 more source

High throughput microbalance and methods of using same [PDF]

, 2007
The method and apparatus is particularly adapted for providing microbalance measurement of solid materials as part of a combinatorial research program.
Carlson, Eric, Gallipeo, John, Kolosov, Oleg, Mazzola, Laura, Spitkovsky, Mikhail   +4 more
core  

Electron Wave Function in Armchair Graphene Nanoribbons

, 2010
By using analytical solution of a tight-binding model for armchair nanoribbons, it is confirmed that the solution represents the standing wave formed by intervalley scattering and that pseudospin is invariant under the scattering.
Albrecht T. R., Areshkin D. A., Begliarbekov M., Cançado L. G., Compernolle S., Cong C., Coratger R., Fujita M., Fujita M., Giunta P. L., Gupta A. K., Jia X., Kelly K. F., Mizes H. A., Niimi Y., Novoselov K. S., Ruffieux P., Rutter G. M., Saito R., Sakai K.-i., Sasaki K., Sasaki K., Sasaki K., Sasaki K., Sato T., Shedd G. M., Tanaka K., Tapasztó L., Treboux G., Valenzuela-Benavides J., Wakabayashi K., Yan J., Yang H., Zheng H., Zhu H. Y.   +34 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Neural Network-Based Kinetic Model for Antisolvent Crystallization of Benzophenone: Construction, Validation, and Mechanistic Interpretation

Crystals
The emergence of artificial neural networks and the widespread application of process analytical technology (PAT) have founded a robust foundation for neural network applications in crystallization research.
Yafei Dong, Shutian Xuanyuan, Chuang Xie, Ying Sun, Xiaomeng Zhou, Yuanhang Wang   +5 more
doaj   +1 more source

High throughput microbalance and methods of using same [PDF]

, 2005
A method and apparatus for measurement of mass of small sample sizes. The method and apparatus is particularly adapted for providing microbalance measurement of solid materials as part of a combinatorial research program.
Carlson, Eric, Kolosov, Oleg, Matsiev, L
core  

Polydisperse Adsorption: Pattern Formation Kinetics, Fractal Properties, and Transition to Order

, 1998
We investigate the process of random sequential adsorption of polydisperse particles whose size distribution exhibits a power-law dependence in the small size limit, $P(R)\sim R^{\alpha-1}$.
A. Yokoyama, B. B. Mandelbrot, B. Bonnier, E. S. Hood, G. S. Baker, G. V. Schulz, J. D. Weeks, J. F. Douglas, J. Feder, J. J. Ramsden, J. Kurths, J. Talbot, J. W. Evans, M. C. Bartelt, M. C. Mackey, M. K. Hassan, N. Standish, N. V. Brilliantov, N. V. Brilliantov, N. V. Brilliantov, P. J. Flory, P. L. Krapivsky, P. L. Krapivsky, P. Meakin, S. S. Manna, W. Soppe, Yu. A. Andrienko, Yu. A. Andrienko   +27 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source