Results 51 to 60 of about 5,516 (293)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Chemometrics-based process analytical technology (PAT) tools: Applications and adaptation in pharmaceutical and biopharmaceutical industries

, 2013
Process analytical technology (PAT) is used to monitor and control critical process parameters in raw materials and in-process products to maintain the critical quality attributes and build quality into the product.
Potumarthi, R., Challa, S.
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Process analytical technology tools for perfusion cell culture

Engineering in Life Sciences, 2016
During cell cultivation processes for the production of biopharmaceuticals, good process performance and good product quality can be ensured by online monitoring of critical process parameters (e.g. temperature, pH, or dissolved oxygen).
Sarah M. Mercier, Perrine M. Rouel, Pierre Lebrun, Bas Diepenbroek, René H. Wijffels, Mathieu Streefland   +5 more
doaj   +1 more source

Review of near-infrared spectroscopy as a process analytical technology for real-time product monitoring in dairy processing [PDF]

, 2020
Real-time process/product monitoring can be achieved using suitable process analytical technologies (PAT) to improve process efficiencies and product quality.
Tobin, John T., O\u27Shea, Norah, O'Shea, Norah, O\u27Donnell, Colm, O'Donnell, Colm, Pu, Yuan-Yuan   +5 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Crystallization process monitoring and control using process analytical technology

, 2023
Kristalizacija je jedinična operacija od velike važnosti u brojnim industrijskim granama, kako u kemijskoj i prehrambenoj industriji, tako i u farmaceutskoj industriji.
Duić, Tea
core   +2 more sources

Neural Network-Based Kinetic Model for Antisolvent Crystallization of Benzophenone: Construction, Validation, and Mechanistic Interpretation

Crystals
The emergence of artificial neural networks and the widespread application of process analytical technology (PAT) have founded a robust foundation for neural network applications in crystallization research.
Yafei Dong, Shutian Xuanyuan, Chuang Xie, Ying Sun, Xiaomeng Zhou, Yuanhang Wang   +5 more
doaj   +1 more source

Designing Robust Process Analytical Technology (PAT) Systems for Crystallization Processes: A Potassium Dichromate Crystallization Case Study [PDF]

, 2013
The objective of this study is to test and validate a Process Analytical Technology (PAT) system design on a potassium dichromate crystallization process in the presence of input uncertainties using uncertainty and sensitivity analysis.
Sin, Gürkan, Abdul Samad, Noor Asma Fazli Bin   +1 more
core  

Process Analytical Technology

, 2013
The term “process analytical technology” (PAT) has been used to describe the application of analytical chemistry and process chemistry combined with the multivariate tools for process understanding. PAT is a wide and complex theme, making it difficult to
Silva, João S., Martins, R., Vicente, A. A., Silva, F., Teixeira, J. A.   +4 more
core   +1 more source