Results 51 to 60 of about 4,485 (254)

Aluminum Phosphate Vaccine Adjuvant: Analysis of Composition and Size Using Off-Line and In-Line Tools

Computational and Structural Biotechnology Journal, 2019
Purpose: Aluminum-based adjuvants including aluminum phosphate (AlPO4) are commonly used in many human vaccines to enhance immune response. The interaction between the antigen and adjuvant, including the physical adsorption of antigen, may play a role in
Carmen Mei, Sasmit Deshmukh, James Cronin, Shuxin Cong, Daniel Chapman, Nicole Lazaris, Liliana Sampaleanu, Ulrich Schacht, Katherine Drolet-Vives, Moriam Ore, Sylvie Morin, Bruce Carpick, Matthew Balmer, Marina Kirkitadze   +13 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Leveraging Microwaves as a Process Analytical Technology (PAT) Tool in the Pharmaceutical Industry

Acta Poloniae Pharmaceutica - Drug Research
To ensure product quality and consistency, as well as compliance with regulatory standards, the pharmaceutical industry has turned to innovative solutions. One such solution is Process Analytical Technology (PAT), which has the potential to transform pharmaceutical manufacturing by enabling real-time monitoring and control of critical parameters and ...
Mateusz Mróz, Małgorzata Sznitowska
openaire   +2 more sources

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

PROCESS ANALYTICAL TECHNOLOGY (PAT) IN PHARMACEUTICAL MANUFACTURING: A REVIEW

EPRA International Journal of Research & Development (IJRD)
Process Analytical Technology (PAT) is a key concept in pharmaceutical manufacturing that involves the use of analytical techniques to monitor and control manufacturing processes in real-time. This review aims to provide an overview of PAT in pharmaceutical manufacturing, including its principles, applications, and benefits.
null Sanjay Saravaiya, null Mohammad Kojar, null Bilal Shaikh, null Priyanshu Upadhyay   +3 more
openaire   +1 more source

Applications of Digital Twins in Biological Industries: An Overview with a Case Study on Fed-Batch Monitoring of Pichia Pastoris Fermentation [PDF]

Iranian Journal of Chemistry & Chemical Engineering
Digital Twins (DTs) are digital representations of physical assets. DTs have emerged as a revolutionary concept in the field of biomanufacturing, offering virtual replicas of physical systems that enable comprehensive monitoring, analysis, and ...
Hossein Rahimi Jafari, Mohammad Fakhroleslam, Seyed Abbas Shojaosadati   +2 more
doaj   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Integration of Serum Neurofilament Light Chain and Cortical Dysfunction Improves Diagnostic Accuracy in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether integration of serum neurofilament light chain (NfL) and cortical dysfunction improves diagnostic accuracy in amyotrophic lateral sclerosis (ALS) when applied alongside the Gold Coast criteria (GCC). Methods In this prospective study, 148 participants with suspected ALS were recruited (101 ALS and 47 with ALS ...
Aicee Dawn Calma, Nathan Pavey, Yukiko Tsuji, Amirul Ab Ghapar, Mehdi A.J. van den Bos, Bronwen Orden, Grace Lee, Linda Mekhael, Julie Ryder, Cláudia Santos Silva, David McDonald, Fakhria Kakar, Con Yiannikas, Matthew C. Kiernan, David A. Brown, Parvathi Menon, Steve Vucic   +16 more
wiley   +1 more source

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source