Results 41 to 50 of about 18,920,531 (281)

Cylindrical IR-ATR Sensors for Process Analytics

Sensors, 2020
Infrared attenuated total reflection (ATR) spectroscopy is a common laboratory technique for the analysis of highly absorbing liquids and solids. However, in a process environment, maintaining a sufficient sample exchange and cleaning of the sensitive ...
Armin Lambrecht, Carsten Bolwien, Jochen Erb, Hendrik Fuhr, Gerd Sulz   +4 more
doaj   +1 more source

Pharmaceutical manufacturing and the quality by design (QBD), process analytical technology (PAT) approach [PDF]

, 2016
This paper is the result of a literature review focusing on the application of process analytical technology (PAT) for the pharmaceutical industry in conjunction with the quality by design (QBD) framework. PAT and the QBD framework put forward by the FDA,
Trevor Murphy, Niall O' Mahony, Joseph Walsh, Daniel Riordan, Niall O'Mahony, Krishna Panduru   +5 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Identifying pharmaceutical manufacturing equipment's surface roughness and mitigating robustness concerns when using specular reflectance Fourier-transform infrared (FTIR) spectroscopy for rapid cleaning verification

Talanta Open, 2022
Preventing cross-contamination during manufacturing is a regulatory requirement in the pharmaceutical manufacturing industry. One element of measures to prevent cross-contamination is the validation of cleaning processes for manufacturing equipment by ...
Apu Sarwar, Conor McSweeney, Joep Timmermans, Eric Moore   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Current PAT Landscape in the Downstream Processing of Biopharmaceuticals

Analytical Science Advances
Protein‐based therapeutics have revolutionized modern medicine, addressing complex diseases with unprecedented specificity and efficacy. The rising demand for biologics has driven the evolution of biomanufacturing practices to ensure consistent quality ...
Pavithra Sathiyapriyan, Shatanik Mukherjee, Thomas Vogel, Lars‐Oliver Essen, David Boerema, Martin Vey, Uwe Kalina   +6 more
doaj   +1 more source

Study on the Growth and Regulation of Large-Particle Sr(OH)₂·8H₂O Crystals with Process Analytical Technology

Crystals, 2023
Sr(OH)2 is an indispensable strontium compound extensively harnessed in sugar refining, strontium lubricating wax formulation, and polymer plastic stabilization. Sr(OH)2·8H2O is the prevalent hydrate form of Sr(OH)2.
Binbin Shi, Yongjuan Zhang, Shudong Liang, Yanan Wang, Yan Jing, Xingwu Zou, Xuezhong Wang   +6 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Process analytical technology (PAT) in continuous bioprocessing [PDF]

, 2017
In recent years biotech companies have been emphasizing on the implementation and utilization of process analytical technology (PAT) in continuous bioprocessing.
Botonjic-Sehic, Edita
core   +1 more source