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, 2021 cite as : Smith, G. (2021) Applications for Electrical Impedance Spectroscopy Process Analytical Technology (EIS-PAT) in Lyophilization Process Development.
Geoff Smith (6064268)
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Artificial Neural Network for Fast and Versatile Model Parameter Adjustment Utilizing PAT Signals of Chromatography Processes for Process Control under Production Conditions [PDF]
, 2022 Preparative chromatography is a well-established operation in chemical and biotechnology manufacturing. Chromatography achieves high separation performances, but often has to deal with the yield versus purity trade-off as the optimization criterium ...
Mourad Mouellef +9 more
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Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
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Talanta Open, 2022 Preventing cross-contamination during manufacturing is a regulatory requirement in the pharmaceutical manufacturing industry. One element of measures to prevent cross-contamination is the validation of cleaning processes for manufacturing equipment by ...
Apu Sarwar +3 more
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Journal of Traditional Chinese Medical Sciences, 2018 Objective: A novel processing analytical framework of Chinese Material Medica (CMM) includes breeding process analysis, planting process analysis, producing process analysis and manufacture process analysis.
Jiangbo Hao +4 more
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Development of process analytical tools for rapid monitoring of live virus vaccines in manufacturing
Scientific Reports, 2022 In the development of end-to-end large-scale live virus vaccine (LVV) manufacturing, process analytical technology (PAT) tools enable timely monitoring of critical process parameters (CPP) and significantly guide process development and characterization.
Sijia Yi +11 more
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A BRIEF REVIEW ON PROCESS ANALYTICAL TECHNOLOGY (PAT) [PDF]
, 2016 Process analytical technology (PAT) has been defined as a mechanism to design, analyze and control pharmaceutical manufacturing processes through measurement of critical process parameters which affect critical quality attributes.
Karekar, P. +3 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Agglomeration Control during Ultrasonic Crystallization of an Active Pharmaceutical Ingredient
Crystals, 2017 Application of ultrasound during crystallization can efficiently inhibit agglomeration. However, the mechanism is unclear and sonication is usually enabled throughout the entire process, which increases the energy demand. Additionally, improper operation
Bjorn Gielen +4 more
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