Results 31 to 40 of about 129,506 (299)

Challenges and Opportunities of Implementing Data Fusion in Process Analytical Technology—A Review

Molecules, 2022
The release of the FDA’s guidance on Process Analytical Technology has motivated and supported the pharmaceutical industry to deliver consistent quality medicine by acquiring a deeper understanding of the product performance and process interplay.
Tibor Casian, Brigitta Nagy, Béla Kovács, Dorián László Galata, Edit Hirsch, Attila Farkas   +5 more
doaj   +1 more source

Machine Learning for Process Monitoring and Control of Hot-Melt Extrusion: Current State of the Art and Future Directions

Pharmaceutics, 2021
In the last few decades, hot-melt extrusion (HME) has emerged as a rapidly growing technology in the pharmaceutical industry, due to its various advantages over other fabrication routes for drug delivery systems. After the introduction of the ‘quality by
Nimra Munir, Michael Nugent, Darren Whitaker, Marion McAfee   +3 more
doaj   +1 more source

Pharmaceutical Application of Process Understanding and Optimization Techniques: A Review on the Continuous Twin-Screw Wet Granulation

Biomedicines, 2023
Twin-screw wet granulation (TSWG) is a method of continuous pharmaceutical manufacturing and a potential alternative method to batch granulation processes.
Jie Zhao, Geng Tian, Haibin Qu
doaj   +1 more source

Modelling the primary drying step for the determination of the optimal dynamic heating pad temperature in a continuous pharmaceutical freeze-drying process for unit doses [PDF]

, 2017
In the pharmaceutical industry, traditional freeze-drying of unit doses is a batch-wise process associated with many disadvantages. To overcome these disadvantages and to guarantee a uniform product quality and high process efficiency, a continuous ...
Corver, Jos, De Beer, Thomas, De Meyer, Laurens, Lammens, Joris, Mortier, Séverine, Nopens, Ingmar, Van Bockstal, Pieter-Jan, Vanbillemont, Brecht, Vervaet, Chris   +8 more
core   +1 more source

Cylindrical IR-ATR Sensors for Process Analytics

Sensors, 2020
Infrared attenuated total reflection (ATR) spectroscopy is a common laboratory technique for the analysis of highly absorbing liquids and solids. However, in a process environment, maintaining a sufficient sample exchange and cleaning of the sensitive ...
Armin Lambrecht, Carsten Bolwien, Jochen Erb, Hendrik Fuhr, Gerd Sulz   +4 more
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Current Industry Perspective on Process Analytical Technique Tools and their Recent Development in Pharmaceutical Oral Solid Dosage Formulations

Journal of Pharmacy
Current review offers extensive understanding and implementation of process analytical technology (PAT) tools in manufacturing of pharmaceutical oral solid dosage (OSD) forms to streamline product’s time to reach to market and increase profitability ...
Chinna Reddy Palem, Vamshi Krishna Lekkala   +1 more
doaj   +1 more source

Study on the Growth and Regulation of Large-Particle Sr(OH)₂·8H₂O Crystals with Process Analytical Technology

Crystals, 2023
Sr(OH)2 is an indispensable strontium compound extensively harnessed in sugar refining, strontium lubricating wax formulation, and polymer plastic stabilization. Sr(OH)2·8H2O is the prevalent hydrate form of Sr(OH)2.
Binbin Shi, Yongjuan Zhang, Shudong Liang, Yanan Wang, Yan Jing, Xingwu Zou, Xuezhong Wang   +6 more
doaj   +1 more source

Effect of particle size distribution on spatially and angularly resolved diffuse reflectance measurement [PDF]

, 2018
Particle size distribution is vitally important in pharmaceutical formulation. Spectroscopy is the most prominent method for in-line particle measurements and process analytics, and near-infrared (NIR) spectroscopy can be seen as the workhorse in the ...
Chen, Yi-Chieh, Ferreira, Carla Sofia, Lue, Leo, Sefcik, Jan, Thennadil, Suresh, Tiernan-Vandermotten, Sarra   +5 more
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source