Results 21 to 30 of about 4,485 (254)

Raman Spectroscopy as a PAT-Tool for Film-Coating Processes: In-Line Predictions Using one PLS Model for Different Cores

Pharmaceutics, 2020
Although Raman spectroscopy has been described as a potential process analytical technique for tablet coating, it has rarely been transferred from academic studies to commercial manufacturing applications.
Juliana Radtke, Hubertus Rehbaum, Peter Kleinebudde   +2 more
doaj   +1 more source

Machine learning and metabolic modelling assisted implementation of a novel process analytical technology in cell and gene therapy manufacturing

Scientific Reports, 2023
Process analytical technology (PAT) has demonstrated huge potential to enable the development of improved biopharmaceutical manufacturing processes by ensuring the reliable provision of quality products.
Thomas Williams, Kevin Kalinka, Rui Sanches, Greg Blanchard-Emmerson, Samuel Watts, Lee Davies, Carol Knevelman, Laura McCloskey, Peter Jones, Kyriacos Mitrophanous, James Miskin, Duygu Dikicioglu   +11 more
doaj   +1 more source

Diamond-Coated Silicon ATR Elements for Process Analytics

Sensors, 2021
Infrared attenuated total reflection (ATR) spectroscopy is a common laboratory technique for the analysis of highly absorbing liquids or solid samples.
Nicolai Arndt, Carsten Bolwien, Gerd Sulz, Frank Kühnemann, Armin Lambrecht   +4 more
doaj   +1 more source

Removal of benzaldehyde from a water/ethanol mixture by applying scavenging techniques

Green Processing and Synthesis, 2017
A presence of carbonyl compounds is very common in the food industry. The nature of such compounds is to be reactive and thus many products involve aldehydes/ketones in their synthetic routes.
Mitic Aleksandar, Skov Thomas, Gernaey Krist V.   +2 more
doaj   +1 more source

Analytical Quality by Design Approach to Test Method Development and Validation in Drug Substance Manufacturing

Journal of Chemistry, 2015
Pharmaceutical industry has been emerging rapidly for the last decade by focusing on product Quality, Safety, and Efficacy. Pharmaceutical firms increased the number of product development by using scientific tools such as QbD (Quality by Design) and PAT
N. V. V. S. S. Raman, Useni Reddy Mallu, Hanimi Reddy Bapatu   +2 more
doaj   +1 more source

Challenges and Opportunities of Implementing Data Fusion in Process Analytical Technology—A Review

Molecules, 2022
The release of the FDA’s guidance on Process Analytical Technology has motivated and supported the pharmaceutical industry to deliver consistent quality medicine by acquiring a deeper understanding of the product performance and process interplay.
Tibor Casian, Brigitta Nagy, Béla Kovács, Dorián László Galata, Edit Hirsch, Attila Farkas   +5 more
doaj   +1 more source

Pharmaceutical Application of Process Understanding and Optimization Techniques: A Review on the Continuous Twin-Screw Wet Granulation

Biomedicines, 2023
Twin-screw wet granulation (TSWG) is a method of continuous pharmaceutical manufacturing and a potential alternative method to batch granulation processes.
Jie Zhao, Geng Tian, Haibin Qu
doaj   +1 more source

Machine Learning for Process Monitoring and Control of Hot-Melt Extrusion: Current State of the Art and Future Directions

Pharmaceutics, 2021
In the last few decades, hot-melt extrusion (HME) has emerged as a rapidly growing technology in the pharmaceutical industry, due to its various advantages over other fabrication routes for drug delivery systems. After the introduction of the ‘quality by
Nimra Munir, Michael Nugent, Darren Whitaker, Marion McAfee   +3 more
doaj   +1 more source

Cylindrical IR-ATR Sensors for Process Analytics

Sensors, 2020
Infrared attenuated total reflection (ATR) spectroscopy is a common laboratory technique for the analysis of highly absorbing liquids and solids. However, in a process environment, maintaining a sufficient sample exchange and cleaning of the sensitive ...
Armin Lambrecht, Carsten Bolwien, Jochen Erb, Hendrik Fuhr, Gerd Sulz   +4 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source