Results 11 to 20 of about 4,485 (254)

Exploiting Fluorescent Reporter Molecules for Process Analytical Technology (PAT)

CHIMIA, 2009
Process Analytical Technology (PAT) launched by the U.S. Food and Drug Administration (FDA) aims to ensure the quality of pharmaceutical products. One important tool to obtain a deeper process understanding is the use of modern real-time process
Tobias Broger, Res P. Odermatt, Pablo Ledergerber, Bernhard Sonnleitner   +3 more
doaj   +3 more sources

Symposium on Process Analytical Technology (PAT) at ILMAC Lausanne 2018

CHIMIA, 2018
David Spichiger, Tobias Merz
doaj   +5 more sources

Process analytical technology (PAT) for biopharmaceuticals [PDF]

Biotechnology Journal, 2011
Process analytical technology (PAT), the regulatory initiative for building in quality to pharmaceutical manufacturing, has a great potential for improving biopharmaceutical production. The recommended analytical tools for building in quality, multivariate data analysis, mechanistic modeling, novel models for interpretation of systems biology data and ...
Glassey J, Gernaey KV, Clemens C, Schulz TW, Oliveira R, Striedner G, Mandenius CF   +6 more
openaire   +3 more sources

The Rocky Road to a Digital Lab

CHIMIA, 2023
The pharmaceutical industry has begun incorporating continuous manufacturing technology in synthetic routes toward active pharmaceutical ingredients (APIs).
Peter Sagmeister, Jason D. Williams, C. Oliver Kappe   +2 more
doaj   +1 more source

In Situ Quantification of Polyhydroxybutyrate in Photobioreactor Cultivations of Synechocystis sp. Using an Ultrasound-Enhanced ATR-FTIR Spectroscopy Probe

Bioengineering, 2021
Polyhydroxybutyrate (PHB) is a very promising alternative to most petroleum-based plastics with the huge advantage of biodegradability. Biotechnological production processes utilizing cyanobacteria as sustainable source of PHB require fast in situ ...
Philipp Doppler, Christoph Gasser, Ricarda Kriechbaum, Ardita Ferizi, Oliver Spadiut   +4 more
doaj   +1 more source

Automated Data Generation for Raman Spectroscopy Calibrations in Multi-Parallel Mini Bioreactors

Sensors, 2022
Raman spectroscopy is an analytical technology for the simultaneous measurement of important process parameters, such as concentrations of nutrients, metabolites, and product titer in mammalian cell culture.
Alexander Graf, Angus Woodhams, Michael Nelson, Douglas D. Richardson, Steven M. Short, Mark Brower, Marek Hoehse   +6 more
doaj   +1 more source

Measurement of Paracetamol Concentration Using an Erbium-Doped Fiber Ring Cavity

Photonics, 2023
Process Analytical Technology (PAT) has been increasingly used in the pharmaceutical industry to monitor essential parameters in real-time during pharmaceutical processes. The concentration of Active Pharmaceutical Ingredients (APIs), such as paracetamol,
Liliana Soares, Rosa Ana Pérez-Herrera, Susana Novais, António Ferreira, Susana Silva, Orlando Frazão   +5 more
doaj   +1 more source

BioTech 2017 Conference Report, Wädenswil, 7./8.9.2017

CHIMIA, 2017
Almost 200 scientists and professionals from academia and industry attended the BioTech 2017 conference at the Zurich University of Applied Sciences (ZHAW) in Wädenswil on 7./8. September 2017.
Caspar Demuth
doaj   +1 more source

Demonstrating Functional Equivalence of Pilot and Production Scale Freeze-Drying of BCG. [PDF]

PLoS ONE, 2016
Process analytical technology (PAT)-tools were used to monitor freeze-drying of Bacille Calmette-Guérin (BCG) at pilot and production scale. Among the evaluated PAT-tools, there is the novel use of the vacuum valve open/close frequency for determining ...
R Ten Have, K Reubsaet, P van Herpen, G Kersten, J-P Amorij   +4 more
doaj   +1 more source

Advances in Twin-Screw Granulation Processing

Pharmaceutics, 2021
Twin-screw granulation (TSG) is a pharmaceutical process that has gained increased interest from the pharmaceutical industry for its potential for the development of oral dosage forms.
Uttom Nandi, Vivek Trivedi, Steven A. Ross, Dennis Douroumis   +3 more
doaj   +1 more source