Results 111 to 120 of about 711,319 (308)
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Applying process capability indices in six sigma
, 2010 博士1970到1980年代間，因日本產品品質的提升，使得它在國際市場深受消費者的喜愛，而美國產品在各地市場的佔有率則節節敗退。摩托羅拉(Motorola)是許多與日本廠商品質競爭失利的公司之一，為了挽回市場佔有率，遂提出六標準差的品質改善策略。在六標準差改善活動中，衡量步驟是一個非常重要的程序，其中標準差個數是常被用於衡量目前品質水準的一個工具。但在產業間，製程能力指標是另一個常被使用來衡量製造業製程水準的工具。企業內部的標準差改善專案是使用標準差個數來衡量品質水準 ...
許昌賢; Hsu, Chang-hsien
core
, 2018 One of the key tasks of the CDD methodology concerns designing capabilities starting from existing business requirements, enterprise models, and other kinds of organizational designs.
Valverde, Francsico +7 more
core +1 more source
Applying Lean Six Sigma DMAIC to Improve Service Logistics in Tunisia’s Public Transport
LogisticsBackground: This study deploys the Lean Six Sigma DMAIC framework to achieve systemic optimization of the school subscription process in Tunisia’s public transport service, a critical administrative operation affecting efficiency and customer ...
Mohamed Karim Hajji +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Applying control theory to capability measurement scales
, 2009 Capability and maturity models are widely accepted. Generally the first three levels of most capability models have the same general goal, a defined repeatable process, but may differ in their implementation of that goal.
McBride, T
core
SCHEME ANALYSIS TREE DIMENSIONS AND TOLERANCES PROCESSING [PDF]
Fiabilitate şi Durabilitate, 2011 This paper presents one of the steps that help us to determine the optimal tolerances depending on thetechnological capability of processing equipment. To determine the tolerances in this way is necessary to takethe study and to represent schematically ...
Constanta RADULESCU +2 more
doaj
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Studies on the assessment process: usage of objective evidence in assessing process capability
, 2010 The Appraisal Assistant process assessment tool has been developed to support the assessment or appraisal of process capability and/or organizational maturity, following approaches consistent with the requirements of ISO/IEC 15504 and the Appraisal ...
Rout, Terry
core +1 more source
The Platform Construction of High-power Electronic Devices Industrialization
机车电传动, 2010 Make a detailed statement of the platform construction of high-power electronic devices industrialization, expound the device structure design, process capability and product testing, product application support and other aspects, and put forward an idea
丁荣军, 张明, 黄建伟
doaj