Results 121 to 130 of about 711,319 (308)

Optimization of injection molding parameters for automotive brake fluid reservoirs: design of experiments study across 27 industrial machines

Frontiers in Materials
This study presents a comprehensive design of experiments (DOE) investigation into warpage reduction for automotive brake fluid reservoir safety-critical components, in which dimensional accuracy directly affects braking system integrity.
Jibran Hussain, Jibran Hussain, Jiang Daping, Zhu Nanyang, Luo Zhenwei, Chen Yong, Zhang Jianfeng, Asif Raza, Anjum Shahzad, Zhou Sen   +9 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Identifying higher capability maturity KPAs of construction organisations; Model refinement through expert interviews

Process improvement has been identified as a mechanism of achieving the much needed performance improvements within the construction industry. Despite the concerns of being an industry with unique characteristics, construction has borrowed some process ...
Amaratunga, Dilanthi, Haigh, Richard, Keraminiyage, Kaushal   +2 more
core  

Role of ‘corporate persistence’ and ‘environmental support’ in building breakthrough capability: Empirical investigation of Samsung’s initiatives in memory and microwave oven business [PDF]

It is now an incontrovertible fact that capabilities are the source of competitive advantage. However, the process through which firms build capabilities over a period of time is only partially understood.
Karna, Amit, Dixit, M. R., Sharma, Sunil
core  

Implementing evaluation of the measurement process in an automotive manufacturer: a case study

, 2003
Reducing process variability is presently an area of much interest in manufacturing organizations. Programmes such as Six Sigma robustly link the financial performance of the organization to the degree of variability present in the processes and products
Antony, Jiju
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Um modelo para a análise da capacidade de processos com ênfase na transformação de dados [PDF]

, 2005
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Produção.O estudo da capacidade de processos se tornou uma ferramenta fundamental do controle estatístico da qualidade, tendo ...
Miranda, Rodrigo Gabriel de
core  

Enterprise Modelling: Establishing the Fundament for Capability Management

, 2018
Enterprise Modelling (EM) is an activity where an integrated model describing different aspects of an enterprise is created. An enterprise model consists of a number of related “sub-models” or perspectives, each describing the enterprise from a ...
Kurt Sandkuhl, Stirna, Janis,, Janis Stirna, Sandkuhl, Kurt, Sandkuhl, Kurt,   +4 more
core   +1 more source