Results 141 to 150 of about 711,319 (308)

Concise Process Improvement Methods [PDF]

open access: yes, 2011
This thesis reviews two methodologies for process improvement; Six Sigma and the Shainin System. A strengthened methodology is developed following the 12-step Six Sigma DMAIC cycle with an added Shainin loop in the Analyse phase to narrow down sources ...
COX, STEVEN
core  

Measuring Process Capability in a Hospital by Using Lean Six Sigma Tools-A Case Study in Bangladesh. [PDF]

open access: yesGlob Adv Health Med, 2020
Chyon BSc FA   +4 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Measuring Regional Innovative Capability [PDF]

open access: yes
Regional innovation environment has experienced remarkable changes in the recent decades. Innovativeness at regional level is seen as a consequence of networked co-operation in a regional innovation system, which sets demands for new kinds of regional ...
Vesa Harmaakorpi, Tomi Tura
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Implementing process capability indices for a complete product

open access: yes, 2009
This study develops a novel procedure for measuring the process capability indices of a complete product with several quality characteristics. The p-values of the estimators of Cpl, Cpu, and Cpp, so that the process works at least 100(1-α)% of the time ...
吳錦全; Wu, Chin-chuan; Kuo, H. L.; Chen, K. S.
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Assessing Multivariate Process Capability in the Presence of Measurements Errors

open access: yes, 2010
Gauge measurement error is often an important source of variability in manufacturing applications. The aim of this work is to study the effect of multivariate measurement errors on multivariate capability indices computed using the principal component ...
SCAGLIARINI, MICHELE
core  

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