Results 91 to 100 of about 641,383 (315)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Statistical Monitoring of Process Capability Index Having One Sided Specification Under Repetitive Sampling Using an Exact Distribution

IEEE Access, 2018
This paper proposes a control chart using repetitive sampling for monitoring process capability index having one-sided specification limit using an exact distribution.
Muhammad Aslam
doaj   +1 more source

Capability Indices for Digitized Industries: A Review and Outlook of Machine Learning Applications for Predictive Process Control

Processes
Leveraging machine learning applications for predictive process control signifies a decisive advancement in manufacturing quality management, transitioning from traditional descriptive to predictive capability indices.
Jan Mayer, Roland Jochem
semanticscholar   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

A Power Transformation for Non-Normal Processes Capability Estimation

IEEE Access
The capability of a process is its ability to produce products that meet predefined requirements in industry and it is measured by capability indices. If data are not normally distributed, other techniques for capability estimation should be taken into ...
Silvija Lavrac, Goran Turk
doaj   +1 more source

Capability Indices for Non-Normal Distribution Using Gini’s Mean Difference as Measure of Variability

IEEE Access, 2016
This paper investigates the efficiency of Gini's mean difference (GMD) as a measure of variability in two commonly used process capability indices (PCIs), i.e., Cp and Cpk.
Muhammad Kashif, Muhammad Aslam, Ali Hussein Al-Marshadi, Chi-Hyuck Jun   +3 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Utility of process capability indices in assessment of quality control processes at a clinical laboratory chain. [PDF]

J Clin Lab Anal, 2021
Dong P, Wang YB, Peng DZ, Wang JJ, Cheng YT, Deng XY, Zheng B, Tao R.   +7 more
europepmc   +1 more source

A review of univariate and multivariate process capability indices

, 2017
This paper offers a review of univariate and multivariate process capability indices (PCIs). PCIs are statistic indicators widely used in the industry to quantify the capability of production processes by relating the variability of the measures of the ...
David de-Felipe, Ernest Benedito
semanticscholar   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source