Results 101 to 110 of about 5,272,056 (327)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Satisfying QTPP of Erythropoietin Biosimilar by QbD through DoE-Derived Downstream Process Engineering. [PDF]

Pharmaceutics, 2023
Nag K, Sarker EH, Kumar S, Chakraborty S, Khan MR, Chowdhury MR, Roy R, Roy R, Biswas BK, Bappi EH, Mohiuddin M, Sultana N.   +11 more
europepmc   +1 more source

Engineering design project : series 1 [PDF]

, 2017
This book is a compilation of engineering design projects which illustrates a detail explanation on the design process including all tools and methods involved in each design stage.

core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Environmental Impacts Assessment in Suspension PVC Production Process Using Computer-Aided Process Engineering. [PDF]

Polymers (Basel), 2023
González-Delgado ÁD, Ramos-Olmos M, Aguilar-Vásquez E.   +2 more
europepmc   +1 more source

Semantic integration process of business components to support information system designers

, 2013
The present work is inscribed within the intersection of two scientific thematic: the engineering by reuse of components and ontologies alignment. The integration of Business Components (BC) is a research problem that has been identified in the field of ...
Elasri, Hicham, Sekkaki, Abderrahim
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Safety Issues in Lithium Ion Batteries: Materials and Cell Design

Frontiers in Energy Research, 2019
As the most widely used energy storage device in consumer electronic and electric vehicle fields, lithium ion battery (LIB) is closely related to our daily lives, on which its safety is of paramount importance. LIB is a typical multidisciplinary product.
Xiangkun Wu, Xiangkun Wu, Kaifang Song, Xiaoyan Zhang, Naifang Hu, Liyuan Li, Wenjie Li, Lan Zhang, Lan Zhang, Haitao Zhang   +9 more
doaj   +1 more source

Process Engineering and Glycosyltransferase Improvement for Short Route Chemoenzymatic Total Synthesis of GM1 Gangliosides. [PDF]

Chemistry, 2023
Yu H, Zhang L, Yang X, Bai Y, Chen X.
europepmc   +1 more source

Implementation of Value Engineering in Heat Treatment Process to Cooling Media Steel ST 41 at PT. XY [PDF]

, 2021
⁠Sumiati ⁠Sumiati, Purwati Purwati, Isna Nugraha   +2 more
openalex   +1 more source