Results 171 to 180 of about 5,272,056 (327)

Analysis and Evaluation of Requirement Engineering Process at NorthBay Solutions

, 2018
Noor Afshan, Kashaf-ad-Dooja
openalex   +1 more source

Systems engineering and the user: Incorporation of user requirements into the SE process [PDF]

This paper is organized into four parts. In the Gestation Phase, I describe the process of starting a new mission and establishing its rough boundaries. Next I show how the scientific experiments are selected.
Naugle, John E.
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Redesign of the Introduction to Engineering Course and its Impact on Students’ Knowledge and Application of the Engineering Design Process [PDF]

, 2016
Haolin Zhu, Benjamin Mertz
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Optimizing lipid-lowering synbiotics: strain screening, synergistic consortium formulation, prebiotic modulation, and freeze-drying process engineering for enhanced stability and efficacy. [PDF]

Food Chem (Oxf)
Zhu W, Borjihan Q, Chen Y, Xia Y.
europepmc   +1 more source

Pipeline Gas Demonstration Plant. Phase I. Abbreviated version demonstration plant process design. Volume 2. Book 2: supplement. Section 3. Demonstration plant area descriptions (plant areas 207 through 216). [Engineering drawings; no text]

, 1980
R. K. Eby
openalex   +2 more sources

Developments in Chemical Engineering & Mineral Processing [PDF]

, 1996
Peter Douglas
openalex   +1 more source

Controlled crystallization and surface engineering of mixed-halide γ-CsPbI2Br inorganic perovskites via guanidinium iodide additive in air-processed perovskite solar cells

, 2023
Sawanta S. Mali, Jyoti V. Patil, Julian A. Steele, Young Hee Jung, Mohammad Khaja Nazeeruddin, Chang Kook Hong   +5 more
openalex   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source