Results 131 to 140 of about 1,503,003 (262)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Using Control Charts to Understand Variation: A Tool for Process Improvement in Healthcare. [PDF]

Glob J Qual Saf Healthc
Wotango BY, Abdana TD, Kidane H, Jote EB, Simeneh GT, Workneh WM.   +5 more
europepmc   +1 more source

Implementing a Robust Process Improvement Program in the Neonatal Intensive Care Unit to Reduce Harm. [PDF]

J Healthc Qual, 2022
Nether KG, Thomas EJ, Khan A, Ottosen MJ, Yager L.   +4 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A real-time rapid cycle process improvement tool for accelerated quality improvement in coronary artery bypass grafting surgery. [PDF]

JTCVS Open
Byrne JG, Chaugle F, Asger W, Willis A, DeRose S, Jones R, Chaugle H.   +6 more
europepmc   +1 more source

A Plan to Transform Primary and Community Care at Catalonia based on a process improvement methodology

, 2023
Coll MS, Manjón S, Salabert J, Pladevall C, Algar D, Benaque A, Soler J, de Echagüen AO.   +7 more
europepmc   +1 more source

Establishing a Reference Procedure Length for Anterior Cervical Fusions: The Role for Standards in Surgical Process Improvement. [PDF]

Cureus, 2022
Bohl M, Kakarla UK, Chang SW, Sethi R, Farrokhi F, Leveque JC.   +5 more
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Rational Utilization of Sugammadex Through Quantitative Twitch Monitoring: A Process Improvement Project at a Large Academic Medical Center. [PDF]

Cureus
Kowalsky M, Montejano J, Pattee J, Rist S, Fernandez-Bustamante A, Gilliland S, Weitzel N.   +6 more
europepmc   +1 more source

Effect of an Emergency Department Process Improvement Package on Suicide Prevention: The ED-SAFE 2 Cluster Randomized Clinical Trial.

JAMA Psychiatry, 2023
Boudreaux ED, Larkin C, Vallejo Sefair A, Ma Y, Li YF, Ibrahim AF, Zeger W, Brown GK, Pelletier L, Miller I, ED-SAFE 2 Investigators.   +10 more
europepmc   +1 more source