A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Simple signage and targeted education can lead to process improvement in acute appendicitis care. [PDF]
Atwood R +8 more
europepmc +1 more source
Place of technology management as a key process area within construction process improvement: A critical analysis [PDF]
Process improvement has been identified as an important strategy to address the current unpredictability and under-achievements of the UK construction industry.
Amaratunga, Dilanthi +2 more
core
JIT Implementation: Integrating Production Planning with Process Improvements [PDF]
N. C. Narayanan
openalex +1 more source
Design of a state of the art reporting system and process improvement for reporting of high complexity single antigen bead data for transplant patients to the electronic medical record [PDF]
Lupita I. Geer +5 more
openalex +1 more source
Hematopoietic (stem) cells—The elixir of life?
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Risk Management Practices in the Purchasing System of an Automotive Company
This paper presents the results of a case study conducted in the purchasing department of Bosch Car Multimedia Portugal, aiming to analyze and improve risk management practices within its project environment. Projects in this department are characterized
Anabela Tereso +2 more
doaj +1 more source
Influence of the autochthonous cellulolytic bacteria on the domestic compost process improvement. [PDF]
Ćwiertniewicz-Wojciechowska M +3 more
europepmc +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source

