Results 51 to 60 of about 3,024,432 (308)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Design of an innovation platform for manufacturing SMES [PDF]

, 2013
This paper reports on the conception of a collaborative, internet-based innovation platform with semantic capabilities, which implements a new methodology for the adoption of a systematic innovation process in globally-acting networked SMEs.
Singh, Lakhvir, Ziarati, Martin, Ziarati, Reza   +2 more
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Analysis and control of surface cracks in a B-bearing continuous casting blooms

High Temperature Materials and Processes
In this work, normal manufacture of a B-bearing steel was hampered by cracks in steel. In order to control these cracks, the formation mechanism has been examined through a comprehensive analysis of crack morphology, element segregation, high temperature
Mao Wenwen, Li Jie, Liu Yong, Yang Chengyu, Gao Yu, Xing Liyong, Liu Xianmin, Li Jie, Zhao Haitao   +8 more
doaj   +1 more source

Reflexivity and flexibility: Complementary routes to innovation? [PDF]

, 2016
Flexibility and reflexivity are essential processes for organisational innovation. The aim of the paper is to investigate their concurrent and interactive contribution in enhancing two innovation outcomes (the organisational openness towards innovation ...
Aiken, Argyris, Avallone, Cohen, Donaldson, Farnese, Hoegl, Koornhof, Lee, Maria Luisa Farnese, Moorman, Roberta Fida, Stefano Livi, Thurston, Verdu, West, Yi, Zaltman   +17 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Eco-efficient sea salt purification via coupled brine washing and elutriation technology: A pathway to high-purity salt for sustainable chlor-alkali industry

Environmental Challenges
High-purity sodium chloride (NaCl) is essential for sustainable chlor-alkali production (CAP). Impurities such as Mg²⁺ and Ca²⁺ in raw rock salt accelerate electrode degradation, cause membrane fouling, and reduce the electrolysis efficiency.
Badrut Tamam Ibnu Ali, Hamzah, Mochammad Ismail, Imam Wahyudi, Anwar Mustafa, Arief Syari'at, Umiati, Sih Parmiyatni, Yenni Bakhtiar, Bonny Agung Wahyuono, Hens Saputra, Irawan Santoso, Kusumawati Dewi Budiarti, Adhi Pramono, Endro Wahju Tjahjono   +14 more
doaj   +1 more source

Implementation of the CDM model to the analisys of the hotel sector [PDF]

, 2016
The main aim of this study was to determine the impact of innovation on productivity in service sector companies — especially those in the hospitality sector — that value the reduction of environmental impact as relevant to the innovation process.
García-Pozo, Alejandro
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Metabolic reset purification program improves antioxidant balance and gut microbiome in individuals transitioning to a healthier diet

Frontiers in Nutrition
A healthy diet helps transition individuals towards numerous long-term metabolic benefits but is challenging to maintain. Supplementation with additional whole food-based concentrates and herbs may support this shift by enhancing metabolic resilience ...
Chinmayee Panda, Ralph Kruse, Kaya Williams, Brea Nance, Maruti Gudavalli, Shirin Pourafshar, Brandon Metzger, Slavko Komarnytsky, Slavko Komarnytsky   +8 more
doaj   +1 more source