Results 121 to 130 of about 323,419 (311)
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Enhancing the function and provisioning of ecosystem services in agriculture: Agroecological principles [PDF]
, 2015 Agroecology is essentially based on the use of biodiversity and ecosystem services in agricultural production, and thus represents a true rupture from the way agriculture has been seen and analysed by mainstream science for over a century.
Hainzelin, Etienne
core
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Combinatorial optimization and metaheuristics [PDF]
, 2006 Today, combinatorial optimization is one of the youngest and most active areas of discrete mathematics. It is a branch of optimization in applied mathematics and computer science, related to operational research, algorithm theory and computational ...
Consoli, S, Darby-Dowman, K
core
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
, 2011 Small-scale magnetic features are present everywhere in the solar photosphere. Theoretical models, numerical calculations, and simulations describing the formation of these features have existed for a few decades, but there are only a few observational ...
Bello González +29 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Environmental Chemistry and SafetyHydrogen (H2) has been regarded as a promising clean energy carrier to address the shortage and pollution of fossil energy. Among various hydrogen generation pathways, electrocatalytic water splitting has become the most promising technology to realize ...
Yulu Zhang +6 more
doaj +1 more source
Process intensification through miniaturization [PDF]
, 2023 Redesigning equipment or combining multiple processes in a continuous production line can result in significant increases in process throughput. Scaling down of processes to increase mass and heat transfer (Fig. 1A), increase surface-to-volume ratios, and shortened diffusion paths can significantly affect the outcome of various chemical and biochemical
openaire +1 more source