Results 131 to 140 of about 323,419 (311)

Livestock farming systems and local development: A review of the multiple dimensions of "Territory" in livestock science [PDF]

open access: yes, 2010
A review of the international literature was carried out, in order to describe how researchers study links between livestock farming and local development (i.e. 'territory'). We highlight three different sets of approaches: the first focused on relations
Dedieu, Benoît   +2 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Triple Space-Time Yield in Discontinuous Antibody Biomanufacturing by Combination of Synergetic Process Intensification Strategies. [PDF]

open access: yesBioengineering (Basel), 2023
Reger LN   +5 more
europepmc   +1 more source

Agricultural intensification in West Africa: insights from Sasakawa Global 2000's experience [PDF]

open access: yes, 1999
High population growth rates and increasing urbanization present a challenge to policy makers in West Africa to motivate and assist farmers in using new technologies to improve productivity and increase agricultural production needed to address ...
Galiba, Marcel, Nubukpo, Kako Kossivi
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Power Intensification of Swelling Process

open access: yes, 2007
Makale, boru şekilli bir parçanın şişirilmesinde ilave eksenel basınç uygulayarak güç yoğunlaştırmanın etkilerini araştırmak üzere yürütülen çalışmaların sonuçlarını özetlemektedir. Eksenel basıncın arttırılması, ?? gerilme indeksini ve gerilme halinin rijitliğini azaltarak şekil değiştirme bölgesindeki malzemenin düzgün akışını sağlamaktadır.
KOSTOV, E., ATANASOVA, M.
openaire   +3 more sources

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